{"hq_id":"hq-c-org-000395","name":"Endosulfan","context":"human_adult","timestamp":"2026-10-27T21:04:10.820Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000395","sha256":"3da634e706244033ca4c2babe1f795c93ba1c33a91e7d264171b009fd929a567"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"stockholm_endosulfan_annex_a_2011","type":"regulatory","title":"Stockholm Convention COP5: Endosulfan Added to Annex A (Elimination) with Specific Exemptions — Global Phase-Out Timeline, Agricultural Worker Deaths, Environmental Persistence Assessment","year":2011},{"id":"epa_endosulfan_cancellation_2010","type":"regulatory","title":"US EPA: Endosulfan Phase-Out Agreement with Makhteshim Agan — Aquatic Life Risk, Worker Safety, Agricultural Worker Poisonings in Developing Countries, Ecological Risk Assessment","year":2010},{"id":"kerala_kasargod_study","type":"regulatory","title":"Government of Kerala / National Institute of Occupational Health: Health Effects of Endosulfan Aerial Spraying in Kasargod District, Kerala — Congenital Malformations, Neurological Disorders, Epidemiological Investigation","year":2001},{"id":"src_pubchem_tox_3224","type":"pubchem","title":"PubChem: Toxicity section (CID 3224)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3224/JSON?heading=Toxicity"},{"id":"r60-2026-10-03-d923-niosh-npgd0251","type":"regulatory","title":"NIOSH Pocket Guide to Chemical Hazards - Endosulfan","url":"https://www.cdc.gov/niosh/npg/npgd0251.html"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"r60-2026-10-02-d983-stockholm-dec-5-3","type":"regulatory","title":"Stockholm Convention COP decision SC-5/3","url":"https://www.pops.int/Portals/0/download.aspx?d=UNEP-POPS-COP.5-SC-5-3.English.pdf"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp41-pdf","type":"assessment","title":"Toxicological Profile for Endosulfan (ATSDR, August 2015)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp41.pdf"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-0235-summary-pdf","type":"assessment","title":"Endosulfan; CASRN 115-29-7: IRIS Chemical Assessment Summary","url":"https://iris.epa.gov/static/pdfs/0235_summary.pdf"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-3224","type":"database","title":"PubChem computed properties for CID 3224 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3224"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"ctx_pred_dtxsid1020560","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID1020560 (Endosulfan)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID1020560"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-3224","type":"database","title":"PubChem computed structure descriptors for CID 3224 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/3224"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:Stockholm Convention:annex a (elimination, with specific exemptions): t","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","aggravating_only:negative_carcinogenicity_dropped:EPA CTX / EPA OPP:human_adult","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":52,"warnings":["unmapped_classification:Stockholm Convention:annex a (elimination, with specific exemptions): t","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","aggravating_only:negative_carcinogenicity_dropped:EPA CTX / EPA OPP:human_adult"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","cat","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}