{"hq_id":"hq-c-org-000394","name":"Alpha-HCH (α-hexachlorocyclohexane)","context":"human_adult","timestamp":"2026-10-27T20:52:54.812Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000394","sha256":"c924287441118d1754a41856eb4cd54e9ff6349ce952304cc210368cf150f5dd"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.552837,"weightedMean":0.552837,"std_dev":0.169544,"confidence_interval_95":[0.3,0.75],"source_positions":[{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1987,"value":0.82,"weight":0.41},{"source":"US EPA","year":2008,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"US EPA","year":2008,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1987,"value":1,"weight":0.41},{"source":"US EPA","year":2008,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1987,"value":0.75,"weight":0.41},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.319781,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_alpha_hch_vol41","type":"iarc_monograph","title":"IARC Monographs Volume 41 / Supplement 7: Hexachlorocyclohexane isomers — α-HCH Group 2B, β-HCH Group 2B, γ-HCH (lindane) Group 2B (later upgraded to Group 1)","year":1987},{"id":"epa_hch_isomers_2008","type":"regulatory","title":"US EPA: Alpha- and Beta-Hexachlorocyclohexane — Cancer Classification Likely Human Carcinogen; Global Distillation and Arctic Contamination; Waste Disposal History","year":2008},{"id":"stockholm_hch_annex_a_2009","type":"regulatory","title":"Stockholm Convention COP4: Alpha-HCH and Beta-HCH Added to Annex A (Elimination) — Global Production Legacy, Waste Disposal Sites, Breast Milk Monitoring","year":2009},{"id":"r60-2026-09-30-d918-iris-landing-162-alpha-hexachlorocyclohexane-alpha-hch","type":"regulatory","title":"alpha-Hexachlorocyclohexane (alpha-HCH) | CASRN 319-84-6 | DTXSID2020684 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=162"},{"id":"src_pubchem_tox_727","type":"pubchem","title":"PubChem: Toxicity section (CID 727)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/727/JSON?heading=Toxicity"},{"id":"r60-2026-10-02-d983-ac4-ctx-apis-data-domains","type":"regulatory","title":"Computational Toxicology and Exposure APIs: Data Domains (EPA CCTE)","url":"https://www.epa.gov/comptox-tools/computational-toxicology-and-exposure-apis-data-domains"},{"id":"r60-2026-10-02-d983-ac4-ctx-dashboard-release-notes","type":"regulatory","title":"CompTox Chemicals Dashboard: Release Notes (EPA)","url":"https://www.epa.gov/chemical-research/comptox-chemicals-dashboard-release-notes"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"doc-2026-10-03-d975-www-atsdr-cdc-gov-toxprofiles-tp43-pdf","type":"assessment","title":"Toxicological Profile for Hexachlorocyclohexane (HCH) (ATSDR, March 2024)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp43.pdf"},{"id":"r60-2026-10-02-d983-stockholm-convention-text-2025","type":"regulatory","title":"Stockholm Convention on Persistent Organic Pollutants: text with Annexes (2025 English)","url":"https://www.pops.int/Portals/0/download.aspx?e=UNEP-POPS-COP-CONVTEXT-2025.English.pdf"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-computed-cid-727","type":"database","title":"PubChem computed properties for CID 727 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/727"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid2020684","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2020684 (Alpha-HCH (α-hexachlorocyclohexane))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2020684"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":51,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}