{"hq_id":"hq-c-org-000394","name":"Alpha-HCH (α-hexachlorocyclohexane)","context":"human_adult","timestamp":"2026-08-28T02:54:05.188Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.552837,"weightedMean":0.552837,"std_dev":0.169544,"confidence_interval_95":[0.5,0.75],"source_positions":[{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1987,"value":0.82,"weight":0.41},{"source":"US EPA","year":2008,"value":0.82,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1987,"value":0.5,"weight":0.41},{"source":"US EPA","year":2008,"value":0.5,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1987,"value":1,"weight":0.41},{"source":"US EPA","year":2008,"value":1,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1987,"value":0.75,"weight":0.41},{"source":"US EPA","year":2008,"value":0.75,"weight":0.41},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.319781,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. US EPA classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_alpha_hch_vol41","type":"iarc_monograph","title":"IARC Monographs Volume 41 / Supplement 7: Hexachlorocyclohexane isomers — α-HCH Group 2B, β-HCH Group 2B, γ-HCH (lindane) Group 2B (later upgraded to Group 1)","year":1987},{"id":"epa_hch_isomers_2008","type":"regulatory","title":"US EPA: Alpha- and Beta-Hexachlorocyclohexane — Cancer Classification Likely Human Carcinogen; Global Distillation and Arctic Contamination; Waste Disposal History","year":2008},{"id":"stockholm_hch_annex_a_2009","type":"regulatory","title":"Stockholm Convention COP4: Alpha-HCH and Beta-HCH Added to Annex A (Elimination) — Global Production Legacy, Waste Disposal Sites, Breast Milk Monitoring","year":2009}],"sources_scope":"record","warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":47,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (single report) (ames: none"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant"]}