{"hq_id":"hq-c-org-000392","name":"Spinosad","context":"human_adult","timestamp":"2026-10-27T20:52:55.063Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000392","sha256":"905ce06b5e71df6989bf069592953759c5ddfef7ce3449ccb4e37cafd9d357ab"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_spinosad_registration_review_2019","type":"regulatory","title":"US EPA: Spinosad Registration Review — biological insecticide (Saccharopolyspora spinosa fermentation); IRAC Group 5; nAChR + GABA chloride channel mechanism; bee acute contact toxicity; aquatic invertebrate toxicity; organic certification; pet product safety (Comfortis, Trifexis); human lice treatment; label timing restrictions for pollinator protection (2019)","year":2019},{"id":"apcc_neonicotinoid_pet_products_2023","type":"veterinary","title":"ASPCA Animal Poison Control Center: Neonicotinoid Insecticide Toxicosis — imidacloprid, nitenpyram, dinotefuran; pet product safety (Advantage, Capstar, Vectra); nAChR mechanism; mammalian vs. insect selectivity; clinical signs and management (2023)","year":2023},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-17754356","type":"database","title":"PubChem computed properties for CID 17754356 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/17754356"},{"id":"pubchem-exp-drugbank-cid-17754356","type":"database","title":"DrugBank, as recorded by PubChem (Experimental Properties, CID 17754356; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/17754356/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-ilo-who-international-chemical-safety-ca-cid-17754356","type":"database","title":"ILO-WHO International Chemical Safety Cards (ICSCs), as recorded by PubChem (Experimental Properties, CID 17754356; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/17754356/JSON?heading=Experimental+Properties"},{"id":"d974-o14-2026-10-03-d968-ecfr-40cfr180-s180.495","type":"regulatory","title":"40 CFR Part 180 (eCFR text as of 24 September 2026): § 180.495 Spinosad; tolerances for residues.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-25/title-40.xml?part=180"},{"id":"pubchem-computed-structure-cid-17754356","type":"database","title":"PubChem computed structure descriptors for CID 17754356 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/17754356"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:IRAC:group 5","unmapped_classification:US EPA:toxicity category iii–iv","unmapped_classification:OMRI:certified for use in certified organic production","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":41,"warnings":["unmapped_classification:IRAC:group 5","unmapped_classification:US EPA:toxicity category iii–iv","unmapped_classification:OMRI:certified for use in certified organic production"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","cat","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}