{"hq_id":"hq-c-org-000391","name":"Sulfoxaflor","context":"human_adult","timestamp":"2026-10-27T20:57:12.045Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000391","sha256":"48d983e301d0ec836bcb85a2c8e1be0e27f4e1e0dc2f15cf0c1ec71b97d4dada"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_sulfoxaflor_reregistration_2016","type":"regulatory","title":"US EPA: Sulfoxaflor Registration Decision — sulfoximine class (IRAC 4C); nAChR mechanism; Ninth Circuit vacatur 2015 (Pollinator Stewardship Council v. EPA); re-registration with pollinator protection label restrictions; bloom application prohibitions; bee toxicity data requirements (2016)","year":2016},{"id":"epa_neonicotinoid_bee_risk_2020","type":"regulatory","title":"US EPA: Neonicotinoid Registration Review — imidacloprid, clothianidin, thiamethoxam, acetamiprid, dinotefuran; bee risk assessment; sublethal effects; colony-level modeling; pollinator exposure through pollen and nectar; aquatic invertebrate toxicity; registration review decision (2020)","year":2020},{"id":"pubchem-computed-cid-16723172","type":"database","title":"PubChem computed properties for CID 16723172 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/16723172"},{"id":"src_pubchem_tox_16723172","type":"pubchem","title":"PubChem: Toxicity section (CID 16723172)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/16723172/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-16723172","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 16723172; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/16723172/JSON?heading=Experimental+Properties"},{"id":"d974-o14-2026-10-03-d968-ecfr-40cfr180-s180.668","type":"regulatory","title":"40 CFR Part 180 (eCFR text as of 24 September 2026): § 180.668 Sulfoxaflor; tolerances for residues.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-25/title-40.xml?part=180"},{"id":"ctx_pred_dtxsid0074687","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0074687 (Sulfoxaflor)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0074687"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-16723172","type":"database","title":"PubChem computed structure descriptors for CID 16723172 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/16723172"}],"sources_scope":"record","derived_markers":[],"warnings":["unmapped_classification:US EPA:toxicity category iii","unmapped_classification:IRAC:group 4c","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":47,"warnings":["unmapped_classification:US EPA:toxicity category iii","unmapped_classification:IRAC:group 4c"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","cat","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}