{"hq_id":"hq-c-org-000387","name":"Thiacloprid","context":"human_adult","timestamp":"2026-10-27T18:12:06.807Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000387","sha256":"3e9f849667a1240f10d14af84fa0aefaa9e62f7058b05356abcf1e6107ee907a"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.508347,"weightedMean":0.508347,"std_dev":0.224383,"confidence_interval_95":[0.3,0.75],"source_positions":[{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.405764,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / EPA OPP classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_neonicotinoid_bee_risk_2020","type":"regulatory","title":"US EPA: Neonicotinoid Registration Review — imidacloprid, clothianidin, thiamethoxam, acetamiprid, dinotefuran; bee risk assessment; sublethal effects; colony-level modeling; pollinator exposure through pollen and nectar; aquatic invertebrate toxicity; registration review decision (2020)","year":2020},{"id":"efsa_thiacloprid_withdrawal_2019","type":"regulatory","title":"EFSA: Thiacloprid Peer Review — endocrine disruption; reproductive toxicity; rat carcinogenicity (liver adenoma, uterine tumors); hormonal mechanism; EU non-renewal of approval; Regulation (EU) 2020/23; comparison with other neonicotinoids (2019)","year":2019},{"id":"r60-2026-09-28-d449-fr-2013-02692-78FR8410-raw","type":"regulatory","title":"78 FR 8410 (2013-02-06) FR Doc 2013-02692: Thiacloprid; Pesticide Tolerances","url":"https://www.federalregister.gov/documents/full_text/text/2013/02/06/2013-02692.txt"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"pubchem-computed-cid-115224","type":"database","title":"PubChem computed properties for CID 115224 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/115224"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02008R1272-20260701","type":"regulatory","title":"Consolidated TEXT: 32008R1272 — EN — 01.07.2026 (Regulation (EC) No 1272/2008, CLP; the consolidation applicable on 2026-09-26)","url":"https://publications.europa.eu/resource/celex/02008R1272-20260701"},{"id":"ctx_pred_dtxsid7034961","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7034961 (Thiacloprid)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7034961"},{"id":"pubchem-computed-structure-cid-115224","type":"database","title":"PubChem computed structure descriptors for CID 115224 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/115224"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:EDC Assessment:endocrine disruptor","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":51,"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:EDC Assessment:endocrine disruptor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","cat","aquatic_life","terrestrial_wildlife","human_teen","human_elderly","human_infant","human_pregnant"]}