{"hq_id":"hq-c-org-000384","name":"Diphacinone","context":"human_adult","risk_level":"moderate","schema":"legacy","note":"Synthesis unavailable: compound lacks vectorizable regulatory classifications. Raw safety data returned.","data":{"risk_level":"moderate","summary":"Diphacinone (Ditrac, Ramik, Ditrac Brown) is a first-generation anticoagulant rodenticide (FGAR) — indandione class, structurally distinct from the hydroxycoumarin SGARs (brodifacoum, difenacoum). Oral LD50 rat ~3 mg/kg; requires multiple feedings over several days for rodent control (vs. single feeding for SGARs). Mechanism: VKOR inhibition, depleting active vitamin K and impairing clotting factor synthesis. Half-life in humans significantly shorter than SGARs (days rather than weeks to months). FGARs remain available to consumers in the US without the PCO-only restrictions applied to SGARs. Human poisoning cases occur from accidental ingestion, most commonly by children accessing bait stations. Treatment: vitamin K1 for typically 2–4 weeks (shorter than SGAR treatment duration); good prognosis with prompt care. Also used in Hawaii and other US territories for invasive rat control in native bird habitat."},"meta":{"synthesis_version":"n/a","timestamp":"2026-05-01T19:36:49.547Z"}}