{"hq_id":"hq-c-org-000382","name":"Difethialone","context":"human_adult","risk_level":"high","schema":"legacy","note":"Synthesis unavailable: compound lacks vectorizable regulatory classifications. Raw safety data returned.","data":{"risk_level":"high","summary":"Difethialone (Generation, Hombre, Baraki) is the most recently registered second-generation anticoagulant rodenticide (SGAR) in the US; it is among the most potent SGARs — oral LD50 rat ~0.56 mg/kg. Mechanism: VKOR inhibition identical to brodifacoum; extreme persistence in tissues. Human poisoning cases are fewer than for brodifacoum or bromadiolone given its more limited distribution, but the clinical course mirrors other SGARs — delayed coagulopathy developing 2–7 days after ingestion, lasting weeks without treatment. Treatment: vitamin K1 (phytonadione) orally for minimum 4–6 weeks with INR monitoring; FFP for acute hemorrhage."},"meta":{"synthesis_version":"n/a","timestamp":"2026-05-01T19:37:00.604Z"}}