{"hq_id":"hq-c-org-000381","name":"Bromadiolone","context":"human_adult","risk_level":"high","schema":"legacy","note":"Synthesis unavailable: compound lacks vectorizable regulatory classifications. Raw safety data returned.","data":{"risk_level":"high","summary":"Bromadiolone (Maki, Contrac, Hawk, Boot Hill) is a second-generation anticoagulant rodenticide (SGAR) with intermediate potency among SGARs — oral LD50 rat ~1.1 mg/kg. It inhibits vitamin K epoxide reductase (VKOR), depleting active vitamin K and preventing synthesis of clotting factors II, VII, IX, and X. Half-life in humans is prolonged (estimated weeks); clinical coagulopathy develops 2–7 days after ingestion and can persist for weeks without treatment. Intentional poisoning (self-harm, homicide by anticoagulant) is documented with bromadiolone; several food contamination incidents in China have involved bromadiolone. Treatment: vitamin K1 (phytonadione) orally for 4–6 weeks; FFP or prothrombin complex concentrate for active severe bleeding. Monitoring INR at treatment cessation is essential."},"meta":{"synthesis_version":"n/a","timestamp":"2026-05-01T19:33:48.658Z"}}