{"hq_id":"hq-c-org-000371","name":"Tetramethrin","context":"human_adult","timestamp":"2026-10-27T20:57:51.017Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000371","sha256":"d69f75efdf84be9e8813c9477342eeb52856712d900b22ceeaf303f1e7ee7178"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.338898,"weightedMean":0.338898,"std_dev":0.149589,"confidence_interval_95":[0.2,0.5],"source_positions":[{"source":"EPA CTX / EPA OPP","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.00274,"disagreement_magnitude":0.377021,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / EPA OPP classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_pyrethroid_reregistration_2011","type":"regulatory","title":"US EPA Pyrethroid Reregistration Eligibility Decision — cypermethrin/deltamethrin/lambda-cyhalothrin/bifenthrin/cyfluthrin/fenvalerate/tau-fluvalinate/fenpropathrin; type I/II classification; aquatic toxicity; cat sensitivity; sodium channel mechanism; human paresthesia; buffer zones (2011)","year":2011},{"id":"aspca_apcc_pyrethroid_2023","type":"veterinary","title":"ASPCA Animal Poison Control Center: Pyrethroid Toxicosis in Cats and Dogs — type I vs type II CS/T syndromes; extreme cat sensitivity (sodium channel/UGT deficiency); bathing decontamination; methocarbamol tremor control; cyproheptadine; lipid emulsion severe cases (2023)","year":2023},{"id":"r60-2026-09-28-d449-nepis-P1007AP2-pdftotext","type":"regulatory","title":"RED Document for Tetramethrin, EPA 738-R-08-012, revised Apr 2010 (NEPIS P1007AP2)","url":"https://nepis.epa.gov/Exe/ZyPDF.cgi/P1007AP2.PDF?Dockey=P1007AP2.PDF"},{"id":"pubchem-computed-cid-83975","type":"database","title":"PubChem computed properties for CID 83975 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/83975"},{"id":"src_pubchem_tox_83975","type":"pubchem","title":"PubChem: Toxicity section (CID 83975)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/83975/JSON?heading=Toxicity"},{"id":"doc-2026-10-02-d975-toxrefdb-3-0-pod-csv","type":"database","title":"EPA ToxRefDB 3.0 point-of-departure release (pod.csv)","url":"https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07?dataset=61147fefe4b0856fdc65639b&space=&folder=6850327be4b096bca8848301"},{"id":"doc-2026-10-03-d975-ecotox-ascii-09-15-2026","type":"database","title":"EPA ECOTOX Knowledgebase ASCII release ecotox_ascii_09_15_2026","url":"https://gaftp.epa.gov/ecotox/ecotox_ascii_09_15_2026.zip"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-83975","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 83975; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/83975/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid6032649","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID6032649 (Tetramethrin)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID6032649"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"pubchem-computed-structure-cid-83975","type":"database","title":"PubChem computed structure descriptors for CID 83975 (computed, not measured; as recorded by PubChem)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/compound/83975"}],"sources_scope":"record","derived_markers":[],"warnings":["year_inferred:EPA CTX / EPA OPP:2021","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":49,"warnings":["year_inferred:EPA CTX / EPA OPP:2021"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","cat","dog","aquatic_life","exposure_dermal","human_teen","human_elderly","human_pregnant"]}