{"hq_id":"hq-c-org-000340","name":"Amitriptyline","context":"human_adult","timestamp":"2026-08-28T01:29:16.317Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"fda_amitriptyline_label_2023","type":"regulatory","title":"FDA Prescribing Information: Amitriptyline (Elavil) — depression; TCA; QRS widening; sodium bicarbonate antidote; anticholinergic; Beers Criteria avoid ≥65yr; pain/migraine off-label; pediatric enuresis; narrow therapeutic index; CYP2D6 polymorphism (2023)","year":2023},{"id":"aspca_apcc_tca_2023","type":"veterinary","title":"ASPCA Animal Poison Control Center: Tricyclic Antidepressant Toxicosis in Dogs — sodium channel blockade; cardiac arrhythmias; ECG monitoring; sodium bicarbonate treatment; anticholinergic toxidrome; toxic dose thresholds; comparison to SSRI toxicity (2023)","year":2023}],"sources_scope":"context","warnings":["unmapped_classification:FDA:approved for depression","unmapped_classification:American Geriatrics Society:strongly avoid in adults ≥65 years","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:FDA:approved for depression","unmapped_classification:American Geriatrics Society:strongly avoid in adults ≥65 years"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}