{"hq_id":"hq-c-org-000339","name":"Trazodone","context":"human_adult","timestamp":"2026-08-28T02:44:07.596Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"fda_trazodone_label_2023","type":"regulatory","title":"FDA Prescribing Information: Trazodone (Desyrel/Oleptro) — MDD; SARI mechanism; priapism warning; insomnia off-label use; orthostatic hypotension; sedation profile; non-addictive hypnotic; favorable OD profile vs TCAs (2023)","year":2023},{"id":"plumb_vet_pharmacology_trazodone","type":"reference","title":"Plumb's Veterinary Drug Handbook: Trazodone — canine situational anxiety; veterinary visit/travel/thunderstorm; post-surgical confinement; 2.5–7 mg/kg dosing; comparison to acepromazine; priapism in dogs; selegiline interaction (2023)","year":2023}],"sources_scope":"context","warnings":["unmapped_classification:FDA:approved for mdd","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":41,"warnings":["unmapped_classification:FDA:approved for mdd"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant"]}