{"hq_id":"hq-c-org-000324","name":"Nitrobenzene","context":"human_adult","timestamp":"2026-10-27T20:51:59.563Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000324","sha256":"1a19f0777c1058372b22f64647b98cc185b0d6902faf988641e655b828b89f3e"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.601945,"weightedMean":0.601945,"std_dev":0.169058,"confidence_interval_95":[0.35,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.748069,"weightedMean":0.748069,"std_dev":0.133581,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.510064,"weightedMean":0.510064,"std_dev":0.263823,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.932564,"weightedMean":0.932564,"std_dev":0.125232,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.788214,"weightedMean":0.788214,"std_dev":0.070965,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.395152,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"niosh_nitrobenzene_2019","type":"regulatory","title":"NIOSH Pocket Guide: Nitrobenzene — PEL 1 ppm (skin); IDLH 200 ppm; methemoglobin formation; methylene blue antidote; aniline feedstock; dermal absorption; urinary p-nitrophenol biomarker (2019)","year":2019,"url":"https://www.cdc.gov/niosh/npg/npgd0450.html"},{"id":"epa_ntp_nitrobenzene","type":"regulatory","title":"NTP Report on Carcinogens: Nitrobenzene — reasonably anticipated human carcinogen; thyroid/liver tumors rodents; HAP Clean Air Act; oil of mirbane historical use; industrial methemoglobinemia outbreaks (2021)","year":2021},{"id":"r60-2026-09-25-d449-iris-79","type":"regulatory","title":"Nitrobenzene | CASRN 98-95-3 | DTXSID3020964 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=79"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-ntp-roc-15th-listed-substances","type":"regulatory","title":"Substances Listed in the Fifteenth Report on Carcinogens","url":"https://ntp.niehs.nih.gov/sites/default/files/ntp/roc/content/listed_substances_508.pdf"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"29 CFR 1910.1000, Tables Z-1 and Z-2 (eCFR editorial compilation, as of 2026-09-22)","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_7416","type":"pubchem","title":"PubChem: Toxicity section (CID 7416)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7416/JSON?heading=Toxicity"},{"id":"r60-2026-09-25-d897-eu-cellar-02004L0037-20240408","type":"regulatory","title":"Consolidated TEXT: 32004L0037 — EN — 08.04.2024","url":"https://publications.europa.eu/resource/celex/02004L0037-20240408"},{"id":"r60-2026-09-29-d899-s1-b07-niosh-npg-npgd0450-nitrobenzene","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Nitrobenzene","url":"https://www.cdc.gov/niosh/npg/npgd0450.html"},{"id":"pubchem-exp-cameo-chemicals-cid-7416","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 7416; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/7416/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid3020964","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3020964 (Nitrobenzene)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3020964"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":55,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","exposure_dermal","human_teen","human_elderly","human_pregnant"]}