{"hq_id":"hq-c-org-000319","name":"Methyl ethyl ketone","context":"human_adult","timestamp":"2026-10-27T20:19:51.732Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000319","sha256":"b0e2a758f2a11d9579da81ecfccffeb1d892d211df218f2b322dae71e20760e6"}]},"risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"niosh_mek_2019","type":"regulatory","title":"NIOSH Pocket Guide: Methyl Ethyl Ketone (MEK) — IDLH 3000 ppm; PEL 200 ppm; n-hexane neuropathy potentiation via CYP2E1; coating/adhesive uses; flash point −9°C; A4 carcinogen classification (2019)","year":2019},{"id":"epa_mek_voc","type":"regulatory","title":"EPA: Methyl Ethyl Ketone — VOC ozone formation; GRAS food flavoring; printing ink solvent; auto refinishing; shoe industry neuropathy outbreaks from MEK+hexane mixtures (2020)","year":2020},{"id":"r60-2026-09-25-d449-iris-71","type":"regulatory","title":"Methyl ethyl ketone (MEK) | CASRN 78-93-3 | DTXSID3021516 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=71"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"29 CFR 1910.1000, Tables Z-1 and Z-2 (eCFR editorial compilation, as of 2026-09-22)","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_6569","type":"pubchem","title":"PubChem: Toxicity section (CID 6569)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6569/JSON?heading=Toxicity"},{"id":"r60-2026-09-25-d897-eu-cellar-02000L0039-20210520","type":"regulatory","title":"Consolidated TEXT: 32000L0039 — EN — 20.05.2021","url":"https://publications.europa.eu/resource/celex/02000L0039-20210520"},{"id":"r60-2026-09-29-d899-s1-b06-niosh-npg-npgd0069-2-butanone","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - 2-Butanone","url":"https://www.cdc.gov/niosh/npg/npgd0069.html"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-6569","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 6569; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6569/JSON?heading=Experimental+Properties"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-6569","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 6569; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6569/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid3021516","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3021516 (Methyl ethyl ketone)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3021516"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:EPA IRIS:data are inadequate for an assessment of human car","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":52,"warnings":["unmapped_classification:OSHA:occupational exposure limit","unmapped_classification:EPA CTX / IRIS:data are inadequate for an assessment of human car","unmapped_classification:EPA IRIS:data are inadequate for an assessment of human car","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","exposure_dermal","human_teen","human_elderly","human_infant","human_pregnant","exposure_ingestion","exposure_ocular","occupational_exposure"]}