{"hq_id":"hq-c-org-000308","name":"Capsaicin","context":"human_adult","timestamp":"2026-08-28T02:46:23.152Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.2,"weightedMean":0.2,"std_dev":0,"confidence_interval_95":[0.2,0.2],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"fda_capsaicin_topical_2020","type":"regulatory","title":"FDA: Capsaicin Topical Products — Qutenza 8% patch approval; neuropathic pain indications; TRPV1 mechanism; GRAS food status; OC spray safety; clinical application protocols (2020)","year":2020},{"id":"niosh_capsaicin_oc_spray","type":"regulatory","title":"NIOSH: Capsaicin and Oleoresin Capsicum (OC) Spray — law enforcement use; respiratory and ocular effects; Scoville scale; GI toxicology; desensitization pharmacology; decontamination methods (2019)","year":2019}],"sources_scope":"context","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":45,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 16 positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}