{"hq_id":"hq-c-org-000307","name":"Pyrethrins","context":"human_adult","timestamp":"2026-10-27T17:54:39.514Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000307","sha256":"3d674c42f8027eb557b15a31a89c76574c0f064791211393bd02ef831ba723f1"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.338898,"weightedMean":0.338898,"std_dev":0.149589,"confidence_interval_95":[0.2,0.5],"source_positions":[{"source":"EPA CTX / EPA OPP","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.00274,"disagreement_magnitude":0.377021,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / EPA OPP classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_pyrethrins_reregistration_2006","type":"regulatory","title":"EPA Reregistration Eligibility Decision (RED): Pyrethrins — sodium channel mechanism; mammalian safety rationale; organic agriculture approval; agricultural worker exposure; food tolerances; photodegradation (2006)","year":2006},{"id":"niosh_pyrethrins_2019","type":"regulatory","title":"NIOSH Pocket Guide: Pyrethrins — dermal irritation; contact sensitization; PBO synergist; agricultural occupational exposure; PPE requirements; skin absorption estimate (2019)","year":2019},{"id":"src_pubchem_tox_60202781","type":"pubchem","title":"PubChem: Toxicity section (CID 60202781)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/60202781/JSON?heading=Toxicity"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"29 CFR 1910.1000 Air contaminants (Tables Z-1, Z-2, Z-3) — eCFR full-text XML, 2026-09-22","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-25-d897-eu-cellar-32006L0015","type":"regulatory","title":"L_2006038EN.01003601.xml","url":"https://publications.europa.eu/resource/celex/32006L0015"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-60202781","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 60202781; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/60202781/JSON?heading=Experimental+Properties"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / EPA OPP:2021","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":43,"warnings":["year_inferred:EPA CTX / EPA OPP:2021"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker","aquatic_life"]}