{"hq_id":"hq-c-org-000299","name":"Carfentanil","context":"human_adult","timestamp":"2026-08-28T02:43:44.465Z","risk_level":"extreme","risk_profile":{"magnitude":{"mean":0.925,"weightedMean":0.925,"std_dev":0,"confidence_interval_95":[0.925,0.925],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.925,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"who_ecdd_carfentanil_2018","type":"regulatory","title":"WHO Expert Committee on Drug Dependence (ECDD): Pre-Review of Carfentanil — 10,000× morphine; large animal immobilizer Wildnil; Moscow theater 130 deaths; CWC Schedule 1; microgram lethal dose; naloxone 20-50 mg reversal; Schedule I (2018)","year":2018},{"id":"dea_carfentanil_2016","type":"regulatory","title":"DEA Drug Enforcement Administration: Carfentanil Threat Advisory — Schedule I; no human medical use; illicit supply contamination 2016+; mass overdose clusters; first responder secondary exposure; surface contamination hazard; immunoassay detection gap (2016)","year":2016}],"sources_scope":"context","warnings":["unmapped_classification:DEA:schedule i controlled substance","unmapped_classification:UN:listed as a controlled substance in the 1961 un si","unmapped_classification:Chemical Weapons Convention:schedule 1 under the australia group controls as a","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":41,"warnings":["unmapped_classification:DEA:schedule i controlled substance","unmapped_classification:UN:listed as a controlled substance in the 1961 un si","unmapped_classification:Chemical Weapons Convention:schedule 1 under the australia group controls as a"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}