{"hq_id":"hq-c-org-000292","name":"PBB-153 (2,2',4,4',5,5'-hexabromobiphenyl)","context":"human_adult","timestamp":"2026-10-27T21:11:54.552Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000292","sha256":"409bedceaf25f1bbf97bba04ac782f97dc79c2781bdba1210c8c64ade0688a0d"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.515789,"weightedMean":0.515789,"std_dev":0.199376,"confidence_interval_95":[0.3,0.7],"source_positions":[{"source":"IARC","year":2016,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2016,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2016,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2016,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2016,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.355331,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_pbb_v41_1986","type":"iarc_monograph","title":"IARC Monographs Vol 41: Some Halogenated Hydrocarbons and Pesticide Exposures — Polybrominated Biphenyls (PBBs) Group 2B (possibly carcinogenic to humans) — superseded by Volume 107 (2016), Group 2A; Michigan PBB crisis 1973; hepatic enzyme induction; thyroid and immune effects; liver tumors in rodents (1986)","year":1986},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid70858838","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID70858838 (PBB-153 (2,2',4,4',5,5'-hexabromobiphenyl))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID70858838"}],"sources_scope":"context","derived_markers":[],"warnings":["limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":41},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}