{"hq_id":"hq-c-org-000287","name":"PCB-118 (2,3',4,4',5-pentachlorobiphenyl)","context":"human_adult","timestamp":"2026-05-01T19:52:48.006Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.650658,"weightedMean":0.650658,"std_dev":0.323986,"confidence_interval_95":[0.95,0.95],"source_positions":[{"source":"IARC","year":2016,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2016,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2016,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2016,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2016,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.4228,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[],"warnings":["unmapped_classification:WHO:tef of 0.00003","unmapped_classification:EFSA:indicator ndl-pcb","limited_synthesis"],"meta":{"synthesis_version":"1.0.0","config_version":"1.0.0","n_sources":2,"db_version":39,"warnings":["unmapped_classification:WHO:tef of 0.00003","unmapped_classification:EFSA:indicator ndl-pcb"]},"schema":"synthesis"}