{"hq_id":"hq-c-org-000287","name":"PCB-118 (2,3',4,4',5-pentachlorobiphenyl)","context":"human_adult","timestamp":"2026-08-28T02:49:52.369Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.650658,"weightedMean":0.650658,"std_dev":0.323986,"confidence_interval_95":[0.95,0.95],"source_positions":[{"source":"IARC","year":2016,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2016,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2016,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2016,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2016,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.4228,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_pcbs_v107_2016","type":"iarc_monograph","title":"IARC Monographs Vol 107: Polychlorinated Biphenyls and Polybrominated Biphenyls — PCBs Group 1 (carcinogenic to humans); sufficient evidence from occupational cohort studies; NHL, melanoma, liver cancer; AhR and non-AhR mechanisms; Aroclor mixtures and dioxin-like congeners evaluated (2016)","year":2016,"url":"https://www.ncbi.nlm.nih.gov/books/NBK361696/"},{"id":"efsa_ndl_pcbs_2005","type":"regulatory","title":"EFSA Scientific Opinion on the Risks to Human Health Related to the Presence of Non-Dioxin-Like Polychlorinated Biphenyls (NDL-PCBs) in Feed and Food — Indicator PCBs: PCB-28, 52, 101, 138, 153, 180; TWI based on hepatotoxicity and thyroid effects; fish as primary dietary source (2005, updated 2010)","year":2005,"url":"https://doi.org/10.2903/j.efsa.2005.284"}],"sources_scope":"context","warnings":["unmapped_classification:WHO:tef of 0.00003","unmapped_classification:EFSA:indicator ndl-pcb","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":40,"warnings":["unmapped_classification:WHO:tef of 0.00003","unmapped_classification:EFSA:indicator ndl-pcb"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}