{"hq_id":"hq-c-org-000285","name":"PCB-153 (2,2',4,4',5,5'-hexachlorobiphenyl)","context":"human_adult","timestamp":"2026-10-27T17:58:03.045Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000285","sha256":"f553e9f782de30852fa302660e5665f44f511a1a89b111a277908aa1d243336a"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.650658,"weightedMean":0.650658,"std_dev":0.323986,"confidence_interval_95":[0.3,0.95],"source_positions":[{"source":"IARC","year":2016,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2016,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2016,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2016,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2016,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.4228,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_pcbs_v107_2016","type":"iarc_monograph","title":"IARC Monographs Vol 107: Polychlorinated Biphenyls and Polybrominated Biphenyls — PCBs Group 1 (carcinogenic to humans); sufficient evidence from occupational cohort studies; NHL, melanoma, liver cancer; AhR and non-AhR mechanisms; Aroclor mixtures and dioxin-like congeners evaluated (2016)","year":2016,"url":"https://www.ncbi.nlm.nih.gov/books/NBK361696/"},{"id":"efsa_ndl_pcbs_2005","type":"regulatory","title":"EFSA Scientific Opinion on the Risks to Human Health Related to the Presence of Non-Dioxin-Like Polychlorinated Biphenyls (NDL-PCBs) in Feed and Food — Indicator PCBs: PCB-28, 52, 101, 138, 153, 180; TWI based on hepatotoxicity and thyroid effects; fish as primary dietary source (2005, updated 2010)","year":2005,"url":"https://doi.org/10.2903/j.efsa.2005.284"},{"id":"src_pubchem_tox_37034","type":"pubchem","title":"PubChem: Toxicity section (CID 37034)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/37034/JSON?heading=Toxicity"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-exp-haz-map-information-on-hazardous-chemica-cid-37034","type":"database","title":"Haz-Map, Information on Hazardous Chemicals and Occupational Diseases, as recorded by PubChem (Experimental Properties, CID 37034; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/37034/JSON?heading=Experimental+Properties"},{"id":"doc-2026-10-02-d-975-s901-d975-tp17-pdf","type":"assessment","title":"Toxicological Profile for Polychlorinated Biphenyls (PCBs) (ATSDR, November 2000)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp17.pdf"},{"id":"ctx_pred_dtxsid2032180","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID2032180 (PCB-153 (2,2',4,4',5,5'-hexachlorobiphenyl))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID2032180"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EFSA:assessed as indicator ndl-pcb with twi established","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":40,"warnings":["unmapped_classification:EFSA:assessed as indicator ndl-pcb with twi established"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}