{"hq_id":"hq-c-org-000283","name":"GenX (HFPO-DA)","context":"human_adult","timestamp":"2026-10-27T20:51:27.084Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000283","sha256":"209bb9f6167849ea63046662811d4e463c60a71fd34830952fe946b9c1543d59"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"efsa_pfas_2020","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain (CONTAM): Risk to Human Health Related to the Presence of Perfluoroalkyl Substances in Food — Group TWI 4.4 ng/kg bw/week (sum PFOA+PFNA+PFHxS+PFOS); childhood vaccine antibody response as critical endpoint; fish, drinking water, food contact materials as primary exposure matrices (2020)","year":2020},{"id":"r60-2026-09-26-d867-cc2-ecfr-40cfr141.61","type":"regulatory","title":"§ 141.61 Maximum contaminant levels for organic contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-24/title-40.xml?part=141&section=141.61"},{"id":"r60-2026-09-28-d899-s2-b03-epa-pfas-npdwr","type":"regulatory","title":"Per- and Polyfluoroalkyl Substances (PFAS) | US EPA","url":"https://www.epa.gov/sdwa/and-polyfluoroalkyl-substances-pfas"},{"id":"r60-2026-09-28-d899-s4-b03-who-pfas-drinking-water","type":"regulatory","title":"Water Sanitation and Health","url":"https://www.who.int/teams/environment-climate-change-and-health/water-sanitation-and-health/chemical-hazards-in-drinking-water/per-and-polyfluoroalkyl-substances"},{"id":"r60-2026-09-28-d899-s2-b03-epa-ha-genx-chemicals-and-pfbs","type":"regulatory","title":"Drinking Water Health Advisories for GenX Chemicals and PFBS | US EPA","url":"https://www.epa.gov/sdwa/drinking-water-health-advisories-genx-chemicals-and-pfbs"},{"id":"r60-2026-09-29-d899-s2-b07-epa-genx-chemicals-toxicity-values-2021","type":"regulatory","title":"Human Health Toxicity Values for Hexafluoropropylene Oxide (HFPO) Dimer Acid and Its Ammonium Salt (CASRN 13252-13-6 and CASRN 62037-80-3) Also Known as “GenX Chemicals”","url":"https://www.epa.gov/system/files/documents/2021-10/genx-chemicals-toxicity-assessment_tech-edited_oct-21-508.pdf"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"ctx_pred_dtxsid70880215","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID70880215 (GenX (HFPO-DA))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID70880215"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:IARC:not classified","unmapped_classification:EFSA:not included in 2020 group twi for pfas","unmapped_classification:WHO:potential public health concern [citation withdraw","unmapped_classification:US EPA:maximum contaminant level (mcl) of 10 ng/l in drin","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":43,"warnings":["unmapped_classification:IARC:not classified","unmapped_classification:EFSA:not included in 2020 group twi for pfas","unmapped_classification:WHO:potential public health concern [citation withdraw","unmapped_classification:US EPA:maximum contaminant level (mcl) of 10 ng/l in drin"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}