{"hq_id":"hq-c-org-000277","name":"Aldrin","context":"human_adult","timestamp":"2026-08-28T02:48:07.030Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.630521,"weightedMean":0.630521,"std_dev":0.197507,"confidence_interval_95":[0.7,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"IARC","year":2019,"value":0.7,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.73786,"weightedMean":0.73786,"std_dev":0.139778,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176},{"source":"IARC","year":2019,"value":0.82,"weight":0.41}]},"recency":{"mean":0.569919,"weightedMean":0.569919,"std_dev":0.258835,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176},{"source":"IARC","year":2019,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.922993,"weightedMean":0.922993,"std_dev":0.131042,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176},{"source":"IARC","year":2019,"value":1,"weight":0.41}]},"specificity":{"mean":0.793637,"weightedMean":0.793637,"std_dev":0.074257,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176},{"source":"IARC","year":2019,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.405764,"warning":null},"outliers":[{"source":"HQ_DIRECT","value":0.3}]},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_oc_pesticides_v53_1991","type":"regulatory","title":"IARC Monographs Volume 53: Occupational Exposures in Insecticide Application, and Some Pesticides — the 1991 aldrin and dieldrin evaluations, superseded by the Volume 117 grouped entity (2016 evaluation); GABA-A receptor inhibition; rapid interconversion of aldrin and dieldrin (1991)","year":1991}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:UNEP:persistent organic pollutant (pop)","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: - (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 3 (score: moderate)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":49,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:UNEP:persistent organic pollutant (pop)","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 1 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: - (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 3 (score: moderate)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}