{"hq_id":"hq-c-org-000272","name":"PCB-126 (3,3',4,4',5-Pentachlorobiphenyl)","context":"human_adult","timestamp":"2026-10-27T20:55:33.004Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000272","sha256":"c969fd37e906d2ce27d7baa2394e7e002e32c794bca3a6f4777e60fb4cb04947"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.694921,"weightedMean":0.694921,"std_dev":0.236849,"confidence_interval_95":[0.475,0.95],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.95,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.411424,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (48th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_pcbs_v100f_2012","type":"regulatory","title":"IARC Monographs Volume 100F: Chemical Agents and Related Occupations — Polychlorinated Biphenyls (PCBs) Group 1; dioxin-like PCBs including PCB-126 and PCB-169 as key congeners; occupational and dietary exposure assessment (2012)","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304398/"},{"id":"efsa_dioxins_2018","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain (CONTAM): Risk for Animal and Human Health Related to the Presence of Dioxins and Dioxin-Like PCBs in Feed and Food — TWI 2 pg WHO-TEQ/kg bw/week; TEF framework (WHO 2005); fatty fish, dairy, meat as primary exposure matrices (2018)","year":2018,"url":"https://doi.org/10.2903/j.efsa.2018.5333"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"src_pubchem_tox_63090","type":"pubchem","title":"PubChem: Toxicity section (CID 63090)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/63090/JSON?heading=Toxicity"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid3032179","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID3032179 (PCB-126 (3,3',4,4',5-Pentachlorobiphenyl))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID3032179"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IARC:2021","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":41,"warnings":["year_inferred:EPA CTX / IARC:2021"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}