{"hq_id":"hq-c-org-000270","name":"2,3,4,7,8-PeCDF (2,3,4,7,8-Pentachlorodibenzofuran)","context":"human_adult","timestamp":"2026-10-27T20:56:52.488Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000270","sha256":"40a4e83a86fb2b139fdafe097839ae07cd8f21f165b9a5c528fec94a40345681"}]},"risk_level":"severe","risk_profile":{"magnitude":{"mean":0.73125,"weightedMean":0.73125,"std_dev":0.236759,"confidence_interval_95":[0.475,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.373343,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (48th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_dioxins_v69_1997","type":"regulatory","title":"IARC Monographs Volume 69: Polychlorinated Dibenzo-para-dioxins and Polychlorinated Dibenzofurans","year":1997},{"id":"efsa_dioxins_2018","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain (CONTAM): Risk for Animal and Human Health Related to the Presence of Dioxins and Dioxin-Like PCBs in Feed and Food — TWI 2 pg WHO-TEQ/kg bw/week; TEF framework (WHO 2005); fatty fish, dairy, meat as primary exposure matrices (2018)","year":2018},{"id":"iarc_pecdf_v100f_2012","type":"regulatory","title":"IARC Monographs Volume 100F: Chemical Agents and Related Occupations","year":2012},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"Monographs available – IARC Monographs on the Identification of Carcinogenic Hazards to Humans","url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:WHO:tef = 0.3","unmapped_classification:EFSA:twi of 2 pg who-teq/kg bw/week","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":39,"warnings":["unmapped_classification:WHO:tef = 0.3","unmapped_classification:EFSA:twi of 2 pg who-teq/kg bw/week"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant"]}