{"hq_id":"hq-c-org-000267","name":"1,2,3,6,7,8-HxCDD (1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin)","context":"human_adult","timestamp":"2026-10-27T20:53:46.070Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000267","sha256":"c8e19b9e32b24f51c6a79a5f5249790384286ee2ac7da5e7480b66894f9bb638"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.535197,"weightedMean":0.535197,"std_dev":0.199451,"confidence_interval_95":[0.35,0.75],"source_positions":[{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.395152,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IRIS classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_dioxins_v69_1997","type":"regulatory","title":"IARC Monographs Volume 69: Polychlorinated Dibenzo-","year":1997},{"id":"efsa_dioxins_2018","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain (CONTAM): Risk for Animal and Human Health Related to the Presence of Dioxins and Dioxin-Like PCBs in Feed and Food — TWI 2 pg WHO-TEQ/kg bw/week; TEF framework (WHO 2005); fatty fish, dairy, meat as primary exposure matrices (2018)","year":2018},{"id":"r60-2026-09-30-d918-iris-landing-166-hexachlorodibenzo-p-dioxin-hxcdd-mixture","type":"regulatory","title":"Hexachlorodibenzo-p-dioxin (HxCDD), mixture of 1,2,3,6,7,8-HxCDD and 1,2,3,7,8,9-HxCDD | CASRN 57653-85-7 | DTXSID0023824 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=166"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"src_pubchem_tox_42540","type":"pubchem","title":"PubChem: Toxicity section (CID 42540)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/42540/JSON?heading=Toxicity"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-42540","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 42540; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/42540/JSON?heading=Experimental+Properties"},{"id":"doc-2026-09-30-d907-29e72b1fdb","type":"assessment","title":"ATSDR Toxicological Profile for Chlorinated Dibenzo-p-Dioxins (CDDs)","url":"https://www.atsdr.cdc.gov/toxprofiles/tp104.pdf"},{"id":"ctx_pred_dtxsid0023824","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0023824 (1,2,3,6,7,8-HxCDD (1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0023824"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","unmapped_classification:IARC:group 3 (not classifiable as to its carcinogenicit","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":44,"warnings":["year_inferred:EPA CTX / IRIS:2021","unmapped_classification:IARC:group 3 (not classifiable as to its carcinogenicit"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}