{"hq_id":"hq-c-org-000267","name":"1,2,3,6,7,8-HxCDD (1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin)","context":"human_adult","timestamp":"2026-08-28T02:48:52.154Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.535197,"weightedMean":0.535197,"std_dev":0.199451,"confidence_interval_95":[0.75,0.75],"source_positions":[{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.395152,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IRIS classifies as higher risk (75th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_dioxins_v69_1997","type":"regulatory","title":"IARC Monographs Volume 69: Polychlorinated Dibenzo-para-dioxins and Polychlorinated Dibenzofurans — TCDD Group 1; other PCDD/PCDF congeners Group 3 (1997); TCDD classification reaffirmed in IARC Volume 100F (2012)","year":1997},{"id":"efsa_dioxins_2018","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain (CONTAM): Risk for Animal and Human Health Related to the Presence of Dioxins and Dioxin-Like PCBs in Feed and Food — TWI 2 pg WHO-TEQ/kg bw/week; TEF framework (WHO 2005); fatty fish, dairy, meat as primary exposure matrices (2018)","year":2018}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IRIS:2021","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":41,"warnings":["year_inferred:EPA CTX / IRIS:2021"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}