{"hq_id":"hq-c-org-000265","name":"1,2,3,7,8-PeCDD (1,2,3,7,8-Pentachlorodibenzo-p-dioxin)","context":"human_adult","timestamp":"2026-10-27T19:56:18.662Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000265","sha256":"cc53da6ce04454411a96711b66614281faf6637aa56b61740928a2a00320fcca"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.475,"weightedMean":0.475,"std_dev":0,"confidence_interval_95":[0.475,0.475],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate to high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"iarc_dioxins_v69_1997","type":"regulatory","title":"IARC Monographs Volume 69: Polychlorinated Dibenzo-","year":1997},{"id":"efsa_dioxins_2018","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain (CONTAM): Risk for Animal and Human Health Related to the Presence of Dioxins and Dioxin-Like PCBs in Feed and Food — TWI 2 pg WHO-TEQ/kg bw/week; TEF framework (WHO 2005); fatty fish, dairy, meat as primary exposure matrices (2018)","year":2018},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"doc-2026-09-30-d907-29e72b1fdb","type":"assessment","title":"ATSDR Toxicological Profile for Chlorinated Dibenzo-p-Dioxins (CDDs)","url":"https://www.atsdr.cdc.gov/toxprofiles/tp104.pdf"},{"id":"ctx_pred_dtxsid7052078","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7052078 (1,2,3,7,8-PeCDD (1,2,3,7,8-Pentachlorodibenzo-p-dioxin))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7052078"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:IARC:group 3 (not classifiable as to carcinogenicity)","unmapped_classification:WHO:toxic equivalency factor (tef = 1.0)","unmapped_classification:EU:included in sum pcdd/f-teq maximum levels","unmapped_classification:EFSA:assessed against tolerable weekly intake (twi) of ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":39,"warnings":["unmapped_classification:IARC:group 3 (not classifiable as to carcinogenicity)","unmapped_classification:WHO:toxic equivalency factor (tef = 1.0)","unmapped_classification:EU:included in sum pcdd/f-teq maximum levels","unmapped_classification:EFSA:assessed against tolerable weekly intake (twi) of "]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}