{"hq_id":"hq-c-org-000250","name":"N-Nitrosopyrrolidine (NPYR)","context":"human_adult","timestamp":"2026-08-28T02:56:34.394Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.590705,"weightedMean":0.590705,"std_dev":0.186225,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.748069,"weightedMean":0.748069,"std_dev":0.133581,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.510064,"weightedMean":0.510064,"std_dev":0.263823,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.932564,"weightedMean":0.932564,"std_dev":0.125232,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.788214,"weightedMean":0.788214,"std_dev":0.070965,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.405764,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_nitrosamines_v17_1978","type":"regulatory","title":"IARC Monographs Volume 17: Some N-Nitroso Compounds — NDMA Group 2A, NDEA Group 2A, NPYR Group 2B, NPIP Group 2B, NDBA Group 2B, NMEA Group 2B, NMBA Group 2B, N-Nitrosomorpholine Group 2B (1978, updated in Supplement 7, 1987)","year":1978},{"id":"efsa_nitrosamines_2023","type":"regulatory","title":"EFSA Panel on Contaminants in the Food Chain (CONTAM): Scientific Opinion on the Risk for Human Health Related to the Presence of Nitrosamines in Food — Group MOE approach for 10 priority nitrosamines in processed meat, fish, and other food categories; benchmark MOE 10,000 (2023)","year":2023}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skinirr2 (score: high)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":45,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 7 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skinirr2 (score: high)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant"]}