{"hq_id":"hq-c-org-000247","name":"Aflatoxin M1 (AFM1)","context":"human_adult","timestamp":"2026-10-27T19:04:27.463Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000247","sha256":"7befeda3c8824b0d245ef0ddbf43c0ac22a2c168648a34e2d1ddeeb647d89536"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.673684,"weightedMean":0.673684,"std_dev":0.299064,"confidence_interval_95":[0.35,0.95],"source_positions":[{"source":"IARC","year":2012,"value":0.95,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2012,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2012,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2012,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2012,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.40775,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_mycotoxins_v82_2002","type":"regulatory","title":"IARC Monographs Volume 82: Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene","year":2002,"url":"https://www.inchem.org/documents/iarc/vol82/82-04.html"},{"id":"efsa_mycotoxins_2020","type":"regulatory","title":"EFSA CONTAM Panel (2020) - Risk assessment of aflatoxins in food (EFSA Journal 18(3):6040), incl. AFM1 dietary exposure and margin-of-exposure for milk","year":2020,"url":"https://doi.org/10.2903/j.efsa.2020.6040"},{"id":"iarc_100f_aflatoxins","type":"regulatory","title":"IARC Monographs Volume 100F: Chemical Agents and Related Occupations","year":2012,"url":"https://www.ncbi.nlm.nih.gov/books/NBK304413/"},{"id":"codex_aflatoxin_m1_milk","type":"regulatory","title":"General Standard for Contaminants and Toxins in Food and Feed (CODEX STAN 193-1995)","year":2018,"url":"https://www.fao.org/input/download/standards/17/CXS_193e_2015.pdf"},{"id":"r60-2026-09-28-d899-s3-b03-cellar-02002L0032-20191128","type":"regulatory","title":"Consolidated TEXT: 32002L0032 — EN — 28.11.2019","url":"https://publications.europa.eu/resource/celex/02002L0032-20191128"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid40891797","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID40891797 (Aflatoxin M1 (AFM1))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID40891797"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":45,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}