{"hq_id":"hq-c-org-000244","name":"BDE-99 (2,2',4,4',5-pentabromodiphenyl ether)","context":"human_adult","timestamp":"2026-10-27T20:56:00.743Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000244","sha256":"ee428aa75adaa8ea484a0fe6d2a45b8ba2daa45309f1a88ada7a6f2c3decd099"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"iarc_pbde_v107_2016","type":"regulatory","title":"IARC Monographs Volume 107: Some Chemicals Used as Solvents and in Polymer Manufacture — Tetrabromobisphenol A (TBBPA) Group 2B; Polybrominated diphenyl ethers and hexabromocyclododecane evaluated as persistent halogenated flame retardants (2016)","year":2016},{"id":"epa_ccl5_2022","type":"regulatory","title":"US EPA: Contaminant Candidate List 5 (CCL5) — Final List of Unregulated Contaminants for Regulatory Evaluation under SDWA (2022); includes nickel, cobalt, vanadium, PFAS, and 97 additional chemical and microbial contaminants","year":2022},{"id":"r60-2026-09-29-d899-s4-b06-iris-landing-1008-bde-99","type":"regulatory","title":"2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) | CASRN 60348-60-9 | DTXSID9030048 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=1008"},{"id":"r60-2026-10-01-dd54-pops-all-pops","type":"regulatory","title":"Stockholm Convention: All POPs (the Convention's own list of listed chemicals, Annexes A, B and C)","url":"https://www.pops.int/TheConvention/ThePOPs/AllPOPs/tabid/2509/Default.aspx"},{"id":"r60-2026-10-01-dd54-pops-new-pops","type":"regulatory","title":"Stockholm Convention: The New POPs (the Convention's own index of listed chemicals)","url":"https://www.pops.int/TheConvention/ThePOPs/TheNewPOPs/tabid/2511/Default.aspx"},{"id":"doc-2026-10-02-2026-10-02-dd43f-atsdr-tp207-pbdes","type":"assessment","title":"Toxicological Profile for Polybrominated Diphenyl Ethers (ATSDR, March 2017)","url":"https://www.atsdr.cdc.gov/ToxProfiles/tp207.pdf"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid9030048","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID9030048 (BDE-99 (2,2',4,4',5-pentabromodiphenyl ether))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID9030048"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":50,"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life"]}