{"hq_id":"hq-c-org-000239","name":"1,2-Dichloropropane (1,2-DCP)","context":"human_adult","timestamp":"2026-08-28T01:29:13.059Z","risk_level":"severe","risk_profile":{"magnitude":{"mean":0.709584,"weightedMean":0.709584,"std_dev":0.259356,"confidence_interval_95":[0.8,0.95],"source_positions":[{"source":"IARC","year":2017,"value":0.95,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.714515,"weightedMean":0.714515,"std_dev":0.150427,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2017,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.627305,"weightedMean":0.627305,"std_dev":0.26675,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2017,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.901108,"weightedMean":0.901108,"std_dev":0.141025,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2017,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.806039,"weightedMean":0.806039,"std_dev":0.079914,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2017,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.40775,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (95th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_12dcp_v110_2017","type":"regulatory","title":"IARC Monographs Volume 110: Some Chemicals Used as Solvents and in Polymer Manufacture — 1,2-Dichloropropane Group 1 (Biliary Tract Cancer, Japanese Printing Workers Epidemic), Methylene Chloride Group 2A (2017)","year":2017,"url":"https://www.ncbi.nlm.nih.gov/books/NBK436277/"},{"id":"epa_sdwa_mclg_vocs","type":"regulatory","title":"US EPA National Primary Drinking Water Regulations (40 CFR 141.61) — 1,2-Dichloropropane MCL 0.005 mg/L (MCLG 0)","year":1989,"url":"https://www.ecfr.gov/current/title-40/chapter-I/subchapter-D/part-141/subpart-G"}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 10 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 10 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to "],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":48,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 10 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 10 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2a (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3b (category 3) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to "]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}