{"hq_id":"hq-c-org-000238","name":"MTBE (methyl tert-butyl ether)","context":"human_adult","timestamp":"2026-08-28T02:51:23.414Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.440171,"weightedMean":0.440171,"std_dev":0.091577,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"EPA CTX / IARC","year":2026,"value":0.5,"weight":0.82},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2026,"value":0.82,"weight":0.82}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2026,"value":1,"weight":0.82}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2026,"value":1,"weight":0.82}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2026,"value":0.75,"weight":0.82}]},"consensus":{"exists":false,"strength":0.389487,"disagreement_magnitude":0.228604,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_mtbe_advisory_1997","type":"regulatory","title":"US EPA: Drinking Water Advisory: Consumer Acceptability Advice and Health Effects Analysis on Methyl Tertiary-Butyl Ether (MTBE) — Taste/Odor Threshold 20–40 μg/L, No Federal MCL Established (1997)","year":1997},{"id":"who_dwq_guidelines_2022","type":"regulatory","title":"WHO Guidelines for Drinking-water Quality (4th edition, incorporating the 1st and 2nd addenda, 2022) — Disinfection Byproducts: THMs, HAAs, Chlorite, Bromate, Chloral Hydrate; Guideline Values and Health Basis","year":2022}],"sources_scope":"context","warnings":["unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:EPA CTX / Health Canada:group via: cepa (unclassifiable with respect to ca","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: not classified (score: low)","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":47,"warnings":["unmapped_classification:EPA CTX / Health Canada:group vi: cepa (unclassifiable with respect to car","unmapped_classification:EPA CTX / Health Canada:group via: cepa (unclassifiable with respect to ca","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 2 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: not classified (score: low)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant"]}