{"hq_id":"hq-c-org-000237","name":"1,1,1-Trichloroethane (methyl chloroform)","context":"human_adult","timestamp":"2026-10-27T17:56:45.353Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000237","sha256":"ac2b154d91f5ca813775b34249e94c546a74ee6f59b349497966cb5e514b5eb5"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.456328,"weightedMean":0.456328,"std_dev":0.24992,"confidence_interval_95":[0.2,0.7],"source_positions":[{"source":"EPA CTX / IARC","year":2022,"value":0.7,"weight":0.36818},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.66405,"weightedMean":0.66405,"std_dev":0.159949,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":0.82,"weight":0.36818}]},"recency":{"mean":0.717526,"weightedMean":0.717526,"std_dev":0.275412,"confidence_interval_95":[0.449,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":0.449,"weight":0.36818}]},"methodology":{"mean":0.853797,"weightedMean":0.853797,"std_dev":0.149952,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":1,"weight":0.36818}]},"specificity":{"mean":0.832848,"weightedMean":0.832848,"std_dev":0.084973,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":0.75,"weight":0.36818}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.393675,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_111tca_v71_1999","type":"regulatory","title":"IARC Monographs Volume 130 — 1,1,1-Trichloroethane and Four Other Industrial Chemicals (2022)","year":1999,"url":"https://www.iarc.who.int/news-events/iarc-monographs-evaluation-of-the-carcinogenicity-of-111-trichloroethane-and-four-other-industrial-chemicals/"},{"id":"epa_sdwa_mclg_vocs","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations — Volatile Organic Chemicals (40 CFR 141.61); TCE MCL 5 μg/L, PCE MCL 5 μg/L, CCl4 MCL 5 μg/L, Chloroform MCL via TTHM, 1,2-DCE MCL 5 μg/L, 1,1,1-TCA MCL 200 μg/L","year":1989},{"id":"r60-2026-09-29-d899-s1-b07x-niosh-npg-npgd0404-methyl-chloroform","type":"regulatory","title":"CDC - NIOSH Pocket Guide to Chemical Hazards - Methyl chloroform","url":"https://www.cdc.gov/niosh/npg/npgd0404.html"},{"id":"r60-2026-09-24-d867-ecfr-29cfr1910.1000","type":"regulatory","title":"§ 1910.1000 Air contaminants.","url":"https://www.ecfr.gov/api/versioner/v1/full/2026-09-22/title-29.xml?part=1910&section=1910.1000"},{"id":"r60-2026-09-27-d820-osha-annotated-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1 | Occupational Safety and Health Administration","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-25-d449-iris-197","type":"regulatory","title":"1,1,1-Trichloroethane | CASRN 71-55-6 | DTXSID0021381 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=197"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_6278","type":"pubchem","title":"PubChem: Toxicity section (CID 6278)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6278/JSON?heading=Toxicity"},{"id":"r60-2026-09-25-d897-eu-cellar-02000L0039-20210520","type":"regulatory","title":"Consolidated TEXT: 32000L0039 — EN — 20.05.2021","url":"https://publications.europa.eu/resource/celex/02000L0039-20210520"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-6278","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 6278; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/6278/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid0021381","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0021381 (1,1,1-Trichloroethane (methyl chloroform))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0021381"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3a (category 2) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin corrosion: in vitro / ex vivo: severe irritat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":50,"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 6.3a (category 2) (score","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin corrosion: in vitro / ex vivo: severe irritat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","human_teen","human_elderly","human_infant","human_pregnant"]}