{"hq_id":"hq-c-org-000237","name":"1,1,1-Trichloroethane (methyl chloroform)","context":"human_adult","timestamp":"2026-06-17T20:27:27.780Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.431496,"weightedMean":0.431496,"std_dev":0.249314,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.7,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.417307,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[],"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin corrosion: in vitro / ex vivo: severe irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":48,"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin corrosion: in vitro / ex vivo: severe irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}