{"hq_id":"hq-c-org-000237","name":"1,1,1-Trichloroethane (methyl chloroform)","context":"human_adult","timestamp":"2026-08-28T02:43:35.793Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.456328,"weightedMean":0.456328,"std_dev":0.24992,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"EPA CTX / IARC","year":2022,"value":0.7,"weight":0.36818},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.66405,"weightedMean":0.66405,"std_dev":0.159949,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":0.82,"weight":0.36818}]},"recency":{"mean":0.717526,"weightedMean":0.717526,"std_dev":0.275412,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":0.449,"weight":0.36818}]},"methodology":{"mean":0.853797,"weightedMean":0.853797,"std_dev":0.149952,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":1,"weight":0.36818}]},"specificity":{"mean":0.832848,"weightedMean":0.832848,"std_dev":0.084973,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2022,"value":0.75,"weight":0.36818}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.393675,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (70th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_111tca_v71_1999","type":"regulatory","title":"IARC Monographs Volume 130 — 1,1,1-Trichloroethane and Four Other Industrial Chemicals (2022)","year":1999,"url":"https://www.iarc.who.int/news-events/iarc-monographs-evaluation-of-the-carcinogenicity-of-111-trichloroethane-and-four-other-industrial-chemicals/"},{"id":"epa_sdwa_mclg_vocs","type":"regulatory","title":"US EPA: National Primary Drinking Water Regulations — Volatile Organic Chemicals (40 CFR 141.61); TCE MCL 5 μg/L, PCE MCL 5 μg/L, CCl4 MCL 5 μg/L, Chloroform MCL via TTHM, 1,2-DCE MCL 5 μg/L, 1,1,1-TCA MCL 200 μg/L","year":1989}],"sources_scope":"context","warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin corrosion: in vitro / ex vivo: severe irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":48,"warnings":["unmapped_classification:EPA CTX / IRIS:inadequate information to assess carcinogenic pote","unmapped_classification:EPA CTX / EPA OPP:group d not classifiable as to human carcinogenici","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin corrosion/irritation - categ","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin corrosion: in vitro / ex vivo: severe irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_inhalation","human_teen","human_elderly","human_infant","human_pregnant"]}