{"hq_id":"hq-c-org-000236","name":"1,2-Dichloroethane (1,2-DCA / EDC)","context":"human_adult","timestamp":"2026-06-21T08:40:20.461Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.566353,"weightedMean":0.566353,"std_dev":0.170044,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.730777,"weightedMean":0.730777,"std_dev":0.143494,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.544216,"weightedMean":0.544216,"std_dev":0.283401,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.916353,"weightedMean":0.916353,"std_dev":0.134526,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.7974,"weightedMean":0.7974,"std_dev":0.076231,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.377021,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:IARC:group 2","unmapped_classification:EPA CTX / IRIS:b2 (probable human carcinogen - based on sufficien","unmapped_classification:EPA CTX / Health Canada:group ii: cepa (probably carcinogenic to humans)","unmapped_classification:EPA CTX / EPA OPP:group b2 probable human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 22 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 22 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to "],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":48,"warnings":["year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:IARC:group 2","unmapped_classification:EPA CTX / IRIS:b2 (probable human carcinogen - based on sufficien","unmapped_classification:EPA CTX / Health Canada:group ii: cepa (probably carcinogenic to humans)","unmapped_classification:EPA CTX / EPA OPP:group b2 probable human carcinogen ","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 22 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 22 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: skin irrit. 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 6.4a (category 2a) (score","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 6.3a (category 2) (score","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to "]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}