{"hq_id":"hq-c-org-000228","name":"Dibromochloromethane (DBCM)","context":"human_adult","timestamp":"2026-10-27T20:55:47.314Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000228","sha256":"5da972c9ce85c0a53246224eb220f34230b0ee4f21aba92bdd43f0eff66672de"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.392599,"weightedMean":0.392599,"std_dev":0.099726,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"EPA CTX / IRIS","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.33516,"disagreement_magnitude":0.363517,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IRIS classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"iarc_thm_v52_1991","type":"regulatory","title":"IARC Monographs Volume 52: Chlorinated Drinking-water; Chlorination By-products; Some Other Halogenated Compounds — Chlorodibromomethane (DBCM) Group 3, Bromoform Group 3, Chloroform Group 2B, Bromodichloromethane (BDCM) Group 2B (1991)","year":1991},{"id":"epa_stage2_dbpr_2006","type":"regulatory","title":"US EPA: Stage 2 Disinfectants and Disinfection Byproducts Rule (40 CFR Parts 141 and 142) — TTHM MCL 80 μg/L, HAA5 MCL 60 μg/L, Locational Running Annual Average, BDCM Cancer Risk Assessment, Bladder Cancer Epidemiology (2006)","year":2006},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"PROPOSITION 65 LIST OF CARCINOGENS OR REPRODUCTIVE TOXICANTS","year":2026,"url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-09-26-d867-cc1-iarc-list-of-classifications-loc-app","type":"regulatory","title":"IARC Monographs, List of Classifications","year":2026,"url":"https://monographs.iarc.who.int/list-of-classifications"},{"id":"r60-2026-09-27-d899-iris-landing-222-dibromochloromethane","type":"regulatory","title":"Dibromochloromethane | CASRN 124-48-1 | DTXSID1020300 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=222"},{"id":"src_pubchem_tox_31296","type":"pubchem","title":"PubChem: Toxicity section (CID 31296)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/31296/JSON?heading=Toxicity"},{"id":"doc-2026-10-03-d975-iris-epa-gov-static-pdfs-0222-summary-pdf","type":"assessment","title":"Dibromochloromethane; CASRN 124-48-1: IRIS Chemical Assessment Summary","url":"https://iris.epa.gov/static/pdfs/0222_summary.pdf"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-cameo-chemicals-cid-31296","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 31296; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/31296/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid1020300","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID1020300 (Dibromochloromethane (DBCM))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID1020300"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / IRIS:2021","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:EPA CTX / CalEPA:chlorodibromomethane (dibromochloromethane) — deli","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":49,"warnings":["year_inferred:EPA CTX / IRIS:2021","unmapped_classification:EPA CTX / IARC:group 3 - not classifiable as to its carcinogenici","unmapped_classification:EPA CTX / CalEPA:chlorodibromomethane (dibromochloromethane) — deli","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant"]}