{"hq_id":"hq-c-org-000226","name":"Bromodichloromethane (BDCM)","context":"human_adult","timestamp":"2026-08-28T02:56:32.678Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.595319,"weightedMean":0.595319,"std_dev":0.165392,"confidence_interval_95":[0.5,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.65,"weight":0.30176},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.752744,"weightedMean":0.752744,"std_dev":0.130378,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1999,"value":0.82,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.53333,"weightedMean":0.53333,"std_dev":0.246789,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1999,"value":0.5,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.936948,"weightedMean":0.936948,"std_dev":0.12223,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1999,"value":1,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.78573,"weightedMean":0.78573,"std_dev":0.069264,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1999,"value":0.75,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / NTP RoC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.314261,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_bdcm_v52_1991","type":"regulatory","title":"IARC Monographs Volume 52: Bromodichloromethane (BDCM) — Group 2B Probable Human Carcinogen, Kidney and Liver Tumors in F344 Rats, Reproductive Epidemiology Studies, Trihalomethane Class (1991)","year":1991},{"id":"epa_stage2_dbpr_2006","type":"regulatory","title":"US EPA: Stage 2 Disinfectants and Disinfection Byproducts Rule (40 CFR Parts 141 and 142) — TTHM MCL 80 μg/L, HAA5 MCL 60 μg/L, Locational Running Annual Average, BDCM Cancer Risk Assessment, Bladder Cancer Epidemiology (2006)","year":2006}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":5,"db_version":46,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / NTP RoC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 5 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}