{"hq_id":"hq-c-org-000217","name":"Nonylphenol (NP) and nonylphenol ethoxylates (NPEs)","context":"human_adult","timestamp":"2026-10-27T20:52:59.706Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000217","sha256":"5fcd32afa50fef28868920af447237f1139809e02cc5aca506601e2a42fd8249"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"eu_nonylphenol_restriction","type":"regulatory","title":"EU: Nonylphenol and Nonylphenol Ethoxylates — Restriction Regulation (Directive 2003/53/EC), Textile Import Restriction (>0.01% NP by weight), Priority Hazardous Substance Classification (Water Framework Directive), EQS 0.3 μg/L, Industrial Detergent Ban, Breast Milk and Cord Blood Biomonitoring (2020)","year":2020},{"id":"epa_np_aquatic_assessment","type":"regulatory","title":"US EPA: Nonylphenol Aquatic Life Criteria — Intersex Fish at 1 μg/L (Vitellogenin Induction), Chronic Aquatic Toxicity, Wastewater Treatment Plant Effluent NP Concentrations, Bioconcentration Factor 300-1,000, and US Voluntary Phase-Out Agreement with Detergent Industry (2005)","year":2005},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02006R1907-20260622","type":"regulatory","title":"Consolidated TEXT: 32006R1907 — EN — 22.06.2026","url":"https://publications.europa.eu/resource/celex/02006R1907-20260622"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP) (secondary: unofficial by its own statement)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d968-echa-candidate-list-xml","type":"regulatory","title":"ECHA Candidate List export (XML, operator-saved 2026-10-02)","url":"https://echa.europa.eu/candidate-list-table"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-67296","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 67296; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/67296/JSON?heading=Experimental+Properties"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:EU:regulated substance","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin corr. 1b","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)","unmapped_classification:Canada, as recorded by ToxValDB:eye irritation: serious eye damage/eye irritation ","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 1c (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2b (category 1b) (scor","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":47,"warnings":["unmapped_classification:EU:regulated substance","unmapped_classification:ECHA (CLP Annex VI):skin irritation: skin corr. 1b","unmapped_classification:Denmark, as recorded by ToxValDB:skin sensitization: skinsens1 (score: high)","unmapped_classification:Canada, as recorded by ToxValDB:eye irritation: serious eye damage/eye irritation ","unmapped_classification:Canada, as recorded by ToxValDB:skin irritation: skin corrosion/irritation - categ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 1 (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: category 1c (score: very high)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:New Zealand, as recorded by ToxValDB:skin irritation: category 8.2b (category 1b) (scor"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}