{"hq_id":"hq-c-org-000216","name":"Di-isononyl phthalate (DINP)","context":"human_adult","timestamp":"2026-09-10T14:18:52.571Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.407895,"weightedMean":0.407895,"std_dev":0.099688,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"IARC","year":2021,"value":0.5,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.672632,"weightedMean":0.672632,"std_dev":0.159501,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2021,"value":0.82,"weight":0.41}]},"recency":{"mean":0.730263,"weightedMean":0.730263,"std_dev":0.24922,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2021,"value":0.5,"weight":0.41}]},"methodology":{"mean":0.861842,"weightedMean":0.861842,"std_dev":0.149532,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2021,"value":1,"weight":0.41}]},"specificity":{"mean":0.828289,"weightedMean":0.828289,"std_dev":0.084735,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2021,"value":0.75,"weight":0.41}]},"consensus":{"exists":false,"strength":0.335413,"disagreement_magnitude":0.319781,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"efsa_phthalate_cumulative_risk","type":"regulatory","title":"EFSA: Cumulative Dietary Risk Assessment — Anti-Androgenic Phthalate Group (DEHP, DBP, BBP, DINP), Group-TDI Derivation, Toddler 99.9th Percentile Exceedance Conclusion, Masculinization Programming Window, and Combined Hazard Index Methodology (2019)","year":2019},{"id":"eu_toy_safety_dinp","type":"regulatory","title":"EU Toy Safety Directive (2009/48/EC, amended): DINP Restriction in Mouthed Toys (<0.1% by weight), Cumulative Phthalate Risk Rationale, Childcare Article Coverage, and Precautionary Classification with DEHP/DBP/BBP Despite Lower Individual Potency (2020)","year":2020}],"sources_scope":"context","warnings":["year_inferred:IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":44,"warnings":["year_inferred:IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}