{"hq_id":"hq-c-org-000216","name":"Di-isononyl phthalate (DINP)","context":"human_adult","timestamp":"2026-10-27T20:54:01.445Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000216","sha256":"72f867a687235645355f3f36031784c4c368578ebbacfdbaff776642bda2d968"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.440171,"weightedMean":0.440171,"std_dev":0.091577,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"IARC","year":2026,"value":0.5,"weight":0.82},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.724274,"weightedMean":0.724274,"std_dev":0.146523,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":2026,"value":0.82,"weight":0.82}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"methodology":{"mean":0.910256,"weightedMean":0.910256,"std_dev":0.137365,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":2026,"value":1,"weight":0.82}]},"specificity":{"mean":0.800855,"weightedMean":0.800855,"std_dev":0.07784,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":2026,"value":0.75,"weight":0.82}]},"consensus":{"exists":false,"strength":0.389487,"disagreement_magnitude":0.228604,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"efsa_phthalate_cumulative_risk","type":"regulatory","title":"EFSA: Cumulative Dietary Risk Assessment — Anti-Androgenic Phthalate Group (DEHP, DBP, BBP, DINP), Group-TDI Derivation, Toddler 99.9th Percentile Exceedance Conclusion, Masculinization Programming Window, and Combined Hazard Index Methodology (2019)","year":2019},{"id":"eu_toy_safety_dinp","type":"regulatory","title":"EU Toy Safety Directive (2009/48/EC, amended): DINP Restriction in Mouthed Toys (<0.1% by weight), Cumulative Phthalate Risk Rationale, Childcare Article Coverage, and Precautionary Classification with DEHP/DBP/BBP Despite Lower Individual Potency (2020)","year":2020},{"id":"r60-2026-09-26-d867-cc1-eurlex-cellar-02006R1907-20260622","type":"regulatory","title":"Consolidated TEXT: 32006R1907 — EN — 22.06.2026","url":"https://publications.europa.eu/resource/celex/02006R1907-20260622"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_590836","type":"pubchem","title":"PubChem: Toxicity section (CID 590836)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/590836/JSON?heading=Toxicity"},{"id":"r60-2026-10-08-d974-tedx-list-full-export","type":"reference_database","title":"TEDX List of Potential Endocrine Disruptors, full export (Excel from the publisher's own search, operator-saved 2026-10-08; list last updated September 2018)","url":"https://endocrinedisruption.org/interactive-tools/tedx-list-of-potential-endocrine-disruptors/search-the-tedx-list"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-590836","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 590836; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/590836/JSON?heading=Experimental+Properties"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":47,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:ECHA eChemPortal, as recorded by ToxValDB:skin sensitisation: in vivo (non-llna): not likely"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}