{"hq_id":"hq-c-org-000211","name":"Methadone","context":"human_adult","timestamp":"2026-08-28T02:40:53.106Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.475,"weightedMean":0.475,"std_dev":0,"confidence_interval_95":[0.475,0.475],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.475,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"samhsa_methadone_otp_regulations","type":"regulatory","title":"SAMHSA: Opioid Treatment Program (OTP) Regulations — Methadone for OUD Treatment, Take-Home Dose Requirements, QTc Monitoring, Long Half-Life Stacking Risk, and Diversion Prevention Protocols (42 CFR Part 8; 2023)","year":2023},{"id":"cdc_methadone_prescribing","type":"regulatory","title":"US CDC: Methadone Prescribing — Disproportionate Overdose Mortality, Pediatric Single-Tablet Fatality Reports, Extended 24–48 Hour Monitoring Window, QTc Prolongation (Torsades de Pointes), and CYP3A4/2D6 Drug Interaction Table (2020)","year":2020}],"sources_scope":"context","warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":46,"warnings":["unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: none, 0 positive / 2"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","dog","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}