{"hq_id":"hq-c-org-000210","name":"Buprenorphine","context":"human_adult","timestamp":"2026-08-28T01:31:20.490Z","risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates low to moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"fda_buprenorphine_oud_treatment","type":"regulatory","title":"US FDA: Buprenorphine — OUD Treatment Approvals (Suboxone, Sublocade, Probuphine), Ceiling Effect on Respiratory Depression, Naloxone Abuse Deterrent Component, Pediatric Exposure Risk, Feline Analgesic Use, and Pregnancy/NOWS Outcomes (2022)","year":2022},{"id":"samhsa_buprenorphine_guidelines","type":"regulatory","title":"SAMHSA: Clinical Practice Guideline for the Treatment of Opioid Use Disorder — Buprenorphine Prescribing, Precipitated Withdrawal Management, Child Exposure Prevention (Suboxone film child-resistant packaging), and Comparison with Methadone (2023)","year":2023}],"sources_scope":"context","warnings":["unmapped_classification:FDA:approved for opioid use disorder (oud) treatment","unmapped_classification:FDA:approved for pain treatment","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":39,"warnings":["unmapped_classification:FDA:approved for opioid use disorder (oud) treatment","unmapped_classification:FDA:approved for pain treatment"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","cat","human_teen","human_elderly","human_infant","human_pregnant","aquatic_life","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}