{"hq_id":"hq-c-org-000190","name":"Saccharin","context":"human_adult","timestamp":"2026-06-17T13:25:31.266Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.405705,"weightedMean":0.405705,"std_dev":0.269083,"confidence_interval_95":[0.25,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"EPA CTX / IARC","year":2021,"value":0.25,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.70254,"weightedMean":0.70254,"std_dev":0.154241,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.599983,"weightedMean":0.599983,"std_dev":0.304626,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.889882,"weightedMean":0.889882,"std_dev":0.144601,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.8124,"weightedMean":0.8124,"std_dev":0.081941,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.353051,"warning":null},"outliers":[{"source":"EPA CTX / CalEPA","value":0.8}]},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[],"warnings":["year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 8 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 8 positive","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: not likely to be sensitizing (","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":47,"warnings":["year_inferred:EPA CTX / IARC:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 8 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 8 positive","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (llna): not likely to ","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: not likely to be sensitizing (","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: studies indicate no signi","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: studies indicate no sign"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer"}