{"hq_id":"hq-c-org-000189","name":"Sodium cyclamate (cyclamate)","context":"human_adult","timestamp":"2026-08-28T02:40:49.390Z","risk_level":"low","risk_profile":{"magnitude":{"mean":0.22315,"weightedMean":0.22315,"std_dev":0.024931,"confidence_interval_95":[0.25,0.25],"source_positions":[{"source":"EPA CTX / IARC","year":2021,"value":0.25,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.2,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / IARC","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.833793,"disagreement_magnitude":0.353051,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / IARC classifies as higher risk (25th percentile), while HQ_DIRECT concludes lower risk (20th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"fda_cyclamate_ban_1969","type":"regulatory","title":"US FDA: Sodium Cyclamate — 1969 Prohibition Order, Bladder Tumor Rat Study Basis, Subsequent Petitions for Re-approval, and Current Banned Status in US Food Supply (2022 status update)","year":2022},{"id":"efsa_cyclamate_opinion_2009","type":"regulatory","title":"EFSA Panel on Food Additives: Re-evaluation of Cyclamate (E952) — ADI 7 mg/kg bw/day, Cyclohexylamine Metabolite Assessment, Safety Confirmation at Dietary Exposure Levels (EFSA Journal 2009;96)","year":2009},{"id":"who_jecfa_cyclamate","type":"regulatory","title":"WHO JECFA: Cyclamate and Sodium Cyclamate — Safety Evaluation, ADI 11 mg/kg bw/day (as cyclamic acid equivalent), Global Regulatory Status, and Repeated Confirmation of Safety at Permitted Use Levels (2019)","year":2019}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":44,"warnings":["year_inferred:EPA CTX / IARC:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: negative (ames: negative, 0 positive"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","human_child","exposure_ingestion","human_teen","human_elderly","human_infant","human_pregnant"]}