{"hq_id":"hq-c-org-000178","name":"Anatoxin-a","context":"human_adult","timestamp":"2026-10-27T20:51:13.146Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000178","sha256":"f920e0e6aaa2533687a97763489f56df0ab1e89aca8015b79303bf1e9e92692e"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.35,"weightedMean":0.35,"std_dev":0,"confidence_interval_95":[0.35,0.35],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"who_cyanotoxins_guidelines_2021","type":"regulatory","title":"WHO: Cyanobacterial Toxins — Anatoxin-a, nAChR Mechanism, VFDF History, Recreational Water Guideline (30 μg/L), Drinking Water Treatment, Freshwater Ecology, and Global HAB Epidemiology (2021 Background Document)","year":2021},{"id":"epa_cyanotoxin_drinking_water","type":"regulatory","title":"US EPA: Cyanotoxins in Drinking Water — Anatoxin-a, Cylindrospermopsin, Microcystins — Health Advisories, Treatment Technologies, Monitoring Guidance, and HAB Early Warning Systems (2019)","year":2019},{"id":"r60-2026-09-28-d899-s4-b02-who-guidelines-recreational-water-quality-vol1-2021-pdftotext","type":"regulatory","title":"Guidelines on recreational water quality. Volume 1: coastal and fresh waters","url":"https://iris.who.int/server/api/core/bitstreams/a7571658-db94-4cc7-b6da-71ea654f927d/content"},{"id":"r60-2026-09-27-d899-who-gdwq-4th-ed-addenda-2026-pdftotext","type":"regulatory","title":"Guidelines for drinking-water quality: fourth edition incorporating the first, second and third addenda","url":"https://iris.who.int/server/api/core/bitstreams/c60cc28e-defe-45ed-b157-71fdd43902bf/content"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"ctx_pred_dtxsid50867064","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID50867064 (Anatoxin-a)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID50867064"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:WHO:recreational health-based reference value of 60 μg","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":42,"warnings":["unmapped_classification:WHO:recreational health-based reference value of 60 μg"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","dog","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ingestion","exposure_ocular","occupational_exposure"]}