{"hq_id":"hq-c-org-000172","name":"Domoic acid","context":"human_adult","timestamp":"2026-10-27T18:49:50.472Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000172","sha256":"8760c05f01c5f4f71eb6adb92d2b93450535ebd63b43ff31abba2acf56d7690f"}]},"risk_level":"high","risk_profile":{"magnitude":{"mean":0.625,"weightedMean":0.625,"std_dev":0,"confidence_interval_95":[0.625,0.625],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates high risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"fda_asp_domoic_acid_shellfish","type":"regulatory","title":"US FDA/CFSAN: Amnesic Shellfish Poisoning (ASP) — Domoic Acid, Pseudo-nitzschia, Regulatory Limit (20 mg/kg), National Shellfish Sanitation Program Monitoring, and 1987 Prince Edward Island Outbreak (2022)","year":2022},{"id":"efsa_marine_biotoxins_asp_2009","type":"regulatory","title":"EFSA Panel on Contaminants: Scientific Opinion on Marine Biotoxins — Domoic Acid (Amnesic Shellfish Toxins), AMPA/Kainate Receptor Mechanism, EU Regulatory Limit, Wildlife Mortality, and California Sea Lion Case Studies (EFSA Journal 2009;1009)","year":2009},{"id":"src_pubchem_tox_5282253","type":"pubchem","title":"PubChem: Toxicity section (CID 5282253)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/5282253/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-5282253","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 5282253; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/5282253/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid20274180","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID20274180 (Domoic acid)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID20274180"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:FDA:20 mg/kg tissue limit in shellfish","unmapped_classification:CODEX:20 mg/kg tissue limit in shellfish","unmapped_classification:EU:20 mg/kg tissue limit in shellfish","unmapped_classification:IARC:not classified","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":46,"warnings":["unmapped_classification:FDA:20 mg/kg tissue limit in shellfish","unmapped_classification:CODEX:20 mg/kg tissue limit in shellfish","unmapped_classification:EU:20 mg/kg tissue limit in shellfish","unmapped_classification:IARC:not classified"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","exposure_dermal","exposure_inhalation","exposure_ocular","occupational_exposure"]}