{"hq_id":"hq-c-org-000153","name":"Pirimiphos-methyl","context":"human_adult","timestamp":"2026-10-27T17:56:44.274Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000153","sha256":"2835758b47e59393512eaa6eacc70666b6bf353d8feaa0a8667fff8af374a3e0"}]},"risk_level":"moderate","risk_profile":{"magnitude":{"mean":0.3,"weightedMean":0.3,"std_dev":0,"confidence_interval_95":[0.3,0.3],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.5,"weightedMean":0.5,"std_dev":0,"confidence_interval_95":[0.5,0.5],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35}]},"recency":{"mean":1,"weightedMean":1,"std_dev":0,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35}]},"methodology":{"mean":0.7,"weightedMean":0.7,"std_dev":0,"confidence_interval_95":[0.7,0.7],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35}]},"specificity":{"mean":0.92,"weightedMean":0.92,"std_dev":0,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0,"warning":"single_source_warning"}},"interpretation":{"summary":"Single source (HQ_DIRECT, 2026) indicates moderate risk.","confidence_note":"Evidence quality varies; interpretation requires caution.","context_note":null,"warning":"single_source_warning"},"sources":[{"id":"epa_pirimiphos_methyl_registration","type":"regulatory","title":"US EPA: Pirimiphos-methyl Registration Eligibility Decision — Dietary Risk Assessment, Grain Storage Residues, and Ecological Risk (1999)","year":1999},{"id":"who_pirimiphos_methyl_specs","type":"regulatory","title":"WHO/FAO: JMPR Monograph — Pirimiphos-methyl Residues in Food, ADI, and WHO Vector Control Use (2003)","year":2003},{"id":"r60-2026-09-29-d899-s4-b06-iris-landing-257-pirimiphos-methyl","type":"regulatory","title":"Pirimiphos-methyl | CASRN 29232-93-7 | DTXSID0024266 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=257"},{"id":"r60-2026-09-28-d899-s4-b04-epa-hhbp-2021","type":"regulatory","title":"2021 Human Health Benchmarks for Pesticides | US EPA","url":"https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides"},{"id":"r60-2026-09-28-d449-inbox-irimiphos-methyl-hhra-EPA-HQ-OPP-2009-0056-0010-pdftotext","type":"regulatory","title":"Pirimiphos-Methyl: Registration Review Draft Human Health Risk Assessment (18 February 2016; D410906) (pdftotext rendering)","url":"https://www.regulations.gov/document/EPA-HQ-OPP-2009-0056-0010"},{"id":"echa-chem-reach-registrations","type":"regulatory","title":"ECHA CHEM, Download all substances: REACH registrations (ECHA's own list of REACH-registered substances)","year":2026,"url":"https://chem.echa.europa.eu/"},{"id":"src_pubchem_tox_34526","type":"pubchem","title":"PubChem: Toxicity section (CID 34526)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/34526/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-hazardous-substances-data-bank-cid-34526","type":"database","title":"Hazardous Substances Data Bank (HSDB), as recorded by PubChem (Experimental Properties, CID 34526; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/34526/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid0024266","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID0024266 (Pirimiphos-methyl)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID0024266"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-10-03-d972-epa-opp-evaluating-pesticides-carcinogenic-potential","type":"regulatory","title":"Evaluating Pesticides for Carcinogenic Potential | US EPA","url":"https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/evaluating-pesticides-carcinogenic-potential"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","aggravating_only:negative_carcinogenicity_dropped:EPA CTX / EPA OPP:human_adult","single_source_warning"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":1,"db_version":51,"warnings":["unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2 (score: high)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","aggravating_only:negative_carcinogenicity_dropped:EPA CTX / EPA OPP:human_adult"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_ingestion","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}