{"hq_id":"hq-c-org-000151","name":"Tetrachlorvinphos (TCVP)","context":"human_adult","timestamp":"2026-10-27T19:07:04.125Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000151","sha256":"1d9ebbe74ed877fb9a1c17c482e3071fa1b61a79918c407156daa7fd2844eb46"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.437953,"weightedMean":0.437953,"std_dev":0.092518,"confidence_interval_95":[0.3,0.5],"source_positions":[{"source":"IARC","year":1991,"value":0.5,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2022,"value":0.5,"weight":0.36818},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35}]},"confidence":{"mean":0.720725,"weightedMean":0.720725,"std_dev":0.148029,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1991,"value":0.82,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2022,"value":0.82,"weight":0.36818}]},"recency":{"mean":0.638473,"weightedMean":0.638473,"std_dev":0.243377,"confidence_interval_95":[0.449,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1991,"value":0.5,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2022,"value":0.449,"weight":0.36818}]},"methodology":{"mean":0.90693,"weightedMean":0.90693,"std_dev":0.138777,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1991,"value":1,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2022,"value":1,"weight":0.36818}]},"specificity":{"mean":0.80274,"weightedMean":0.80274,"std_dev":0.07864,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1991,"value":0.75,"weight":0.41},{"source":"EPA CTX / EPA OPP","year":2022,"value":0.75,"weight":0.36818}]},"consensus":{"exists":false,"strength":0.383213,"disagreement_magnitude":0.319781,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. IARC classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (30th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_53_pesticides","type":"regulatory","title":"IARC Monographs Volume 112: Some Organophosphate Insecticides and Herbicides","year":1991},{"id":"epa_tetrachlorvinphos_registration","type":"regulatory","title":"US EPA: Tetrachlorvinphos (TCVP) Registration Review — IARC 2B Classification, Pet Flea Collar Petting Pathway, Children's Cancer Risk, and NRDC Petition Response (2016)","year":2016},{"id":"r60-2026-09-28-d449-epa-tcvp-nrdc-petition-response-2022-10-06-pdftotext","type":"regulatory","title":"Agency Response to the Natural Resources Defense Council’s (NRDC) April 2009 Tetrachlorvinphos Petition","url":"https://www.epa.gov/system/files/documents/2022-10/TCVP%20Final%20Petition%20Response_10-6-22_0.pdf"},{"id":"r60-2026-09-24-d869-iarc-monographs-available","type":"regulatory","title":"IARC Monographs — Monographs available (index)","year":2026,"url":"https://monographs.iarc.who.int/monographs-available/"},{"id":"r60-2026-10-02-d-955-s9-d955-s9-osha-table-z-1","type":"regulatory","title":"Permissible Exposure Limits – OSHA Annotated Table Z-1","url":"https://www.osha.gov/annotated-pels/table-z-1"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"ctx_pred_dtxsid1021320","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID1021320 (Tetrachlorvinphos (TCVP))","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID1021320"}],"sources_scope":"context","derived_markers":[],"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":3,"db_version":52,"warnings":["unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: negativ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","dog","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}