{"hq_id":"hq-c-org-000142","name":"Dimethoate","context":"human_adult","timestamp":"2026-10-27T19:05:56.488Z","derived_by":{"label":"ALETHEIA-derived","engine":{"commit":"a1c6e861599cc34c5db0318ea1a7ac13a327e074","commit_source":"vercel_env","tree_clean":null},"params":{"sha256":"88ae43137e58ed0cd65588409efefee0d90253da01ef4459bf9ee25f888ec9a0","files":["axes.json","context-specificity.json","regulatory-mappings.json","synthesis-params.json","thresholds.json"]},"clock":{"year":2026},"inputs":[{"id":"hq-c-org-000142","sha256":"fb06d77fca63c1c9e03bc75f6c7aaa4c99dc144586523d74b8a59f375adcf8e1"}]},"risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.419449,"weightedMean":0.419449,"std_dev":0.074794,"confidence_interval_95":[0.35,0.5],"source_positions":[{"source":"EPA CTX / EPA OPP","year":2021,"value":0.5,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.35,"weight":0.35}]},"confidence":{"mean":0.648158,"weightedMean":0.648158,"std_dev":0.159561,"confidence_interval_95":[0.5,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.707389,"weightedMean":0.707389,"std_dev":0.315133,"confidence_interval_95":[0.368,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.838898,"weightedMean":0.838898,"std_dev":0.149589,"confidence_interval_95":[0.7,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.841291,"weightedMean":0.841291,"std_dev":0.084767,"confidence_interval_95":[0.75,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"EPA CTX / EPA OPP","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.501373,"disagreement_magnitude":0.358671,"warning":"limited_synthesis"}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / EPA OPP classifies as higher risk (50th percentile), while HQ_DIRECT concludes lower risk (35th percentile).","confidence_note":"Moderate-quality evidence base.","context_note":null,"warning":"limited_synthesis"},"sources":[{"id":"epa_dimethoate_registration","type":"regulatory","title":"US EPA: Dimethoate Registration Review — Dietary and Occupational Risk Assessment, Omethoate Metabolite Toxicity, and Ecological Risk (2016)","year":2016},{"id":"efsa_dimethoate_review","type":"regulatory","title":"EFSA: Peer Review of Dimethoate — Omethoate Reproductive Toxicity, EU Non-Renewal of Approval, Groundwater Monitoring (2016)","year":2016},{"id":"r60-2026-09-29-d899-s4-b06-iris-landing-44-dimethoate","type":"regulatory","title":"Dimethoate | CASRN 60-51-5 | DTXSID7020479 | IRIS | US EPA, ORD","url":"https://iris.epa.gov/ChemicalLanding/&substance_nmbr=44"},{"id":"r60-2026-09-28-d899-s4-b04-epa-hhbp-2021","type":"regulatory","title":"2021 Human Health Benchmarks for Pesticides | US EPA","url":"https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides"},{"id":"r60-2026-09-28-d449-fr-95-16432-60FR34945-raw","type":"regulatory","title":"60 FR 34945 (1995-07-05) FR Doc 95-16432: Dimethoate; Pesticide Tolerance","url":"https://www.federalregister.gov/documents/full_text/text/1995/07/05/95-16432.txt"},{"id":"src_pubchem_tox_3082","type":"pubchem","title":"PubChem: Toxicity section (CID 3082)","url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3082/JSON?heading=Toxicity"},{"id":"r60-2026-09-30-d918-oehha-prop65-list-csv-own-url","type":"regulatory","title":"OEHHA Proposition 65 List of Carcinogens or Reproductive Toxicants (CSV, list date 31-Jul-26)","url":"https://oehha.ca.gov/sites/default/files/media/2025-01/p65chemicalslist.csv"},{"id":"pubchem-exp-cameo-chemicals-cid-3082","type":"database","title":"CAMEO Chemicals, as recorded by PubChem (Experimental Properties, CID 3082; where-to-look, not a source of this value)","year":2026,"url":"https://pubchem.ncbi.nlm.nih.gov/rest/pug_view/data/compound/3082/JSON?heading=Experimental+Properties"},{"id":"ctx_pred_dtxsid7020479","type":"reference","title":"EPA CompTox CTX API: predicted properties for DTXSID7020479 (Dimethoate)","url":"https://comptox.epa.gov/ctx-api/chemical/property/predicted/search/by-dtxsid/DTXSID7020479"},{"id":"r60-2026-10-01-echa-annex-vi-clp-table-atp23-xlsx","type":"regulatory","title":"ECHA Annex VI to CLP: the unofficial Excel table (up to and including the 23rd ATP)","url":"https://echa.europa.eu/documents/10162/17218/annex_vi_clp_table_atp23_en.xlsx/b3816c13-81a3-816d-773a-62e88c4e2700?t=1761727004499"},{"id":"r60-2026-10-03-d972-epa-opp-evaluating-pesticides-carcinogenic-potential","type":"regulatory","title":"Evaluating Pesticides for Carcinogenic Potential | US EPA","url":"https://www.epa.gov/pesticide-science-and-assessing-pesticide-risks/evaluating-pesticides-carcinogenic-potential"}],"sources_scope":"context","derived_markers":[],"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:EDC Assessment:reproductive toxicant","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score","limited_synthesis"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":2,"db_version":53,"warnings":["year_inferred:EPA CTX / EPA OPP:2021","unmapped_classification:EDC Assessment:reproductive toxicant","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:US EPA (CompTox genotoxicity summary):epa comptox computed genotoxicity summary: positiv","unmapped_classification:Australia, as recorded by ToxValDB:skin sensitization: skin sensitisation - category ","unmapped_classification:Japan, as recorded by ToxValDB:eye irritation: category 2b (score: moderate)","unmapped_classification:Japan, as recorded by ToxValDB:skin irritation: not classified (score: low)","unmapped_classification:Japan, as recorded by ToxValDB:skin sensitization: not classified (score: low)","unmapped_classification:New Zealand, as recorded by ToxValDB:eye irritation: category 6.4a (category 2a) (score"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}