{"hq_id":"hq-c-org-000140","name":"Parathion (ethyl parathion)","context":"human_adult","timestamp":"2026-08-28T01:29:34.033Z","risk_level":"high","risk_profile":{"magnitude":{"mean":0.598479,"weightedMean":0.598479,"std_dev":0.119292,"confidence_interval_95":[0.625,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"HQ_DIRECT","year":2026,"value":0.625,"weight":0.35},{"source":"IARC","year":1983,"value":0.5,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.5,"weight":0.30176}]},"confidence":{"mean":0.73786,"weightedMean":0.73786,"std_dev":0.139778,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"IARC","year":1983,"value":0.82,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.82,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.569919,"weightedMean":0.569919,"std_dev":0.258835,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"IARC","year":1983,"value":0.5,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.368,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.922993,"weightedMean":0.922993,"std_dev":0.131042,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"IARC","year":1983,"value":1,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":1,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.793637,"weightedMean":0.793637,"std_dev":0.074257,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"IARC","year":1983,"value":0.75,"weight":0.41},{"source":"EPA CTX / IRIS","year":2021,"value":0.75,"weight":0.30176},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0.20472,"disagreement_magnitude":0.312066,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while EPA CTX / IRIS concludes lower risk (50th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"iarc_30_pesticides","type":"regulatory","title":"IARC Monographs Volume 30: Occupational Exposures in Insecticide Application and Some Pesticides — Parathion and Methyl Parathion Group 2B Classification (1983)","year":1983},{"id":"who_parathion_criteria","type":"regulatory","title":"WHO Environmental Health Criteria 79: Parathion — Acute Neurotoxicity, AChE Inhibition, Occupational Exposure, and Ecological Risk (1992)","year":1992}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 4 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 4 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":49,"warnings":["year_inferred:EPA CTX / IRIS:2021","year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 4 positive","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 4 positive","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 2b (score: moderate)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: not classified (score: low)"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_inhalation","exposure_dermal","aquatic_life","human_teen","human_elderly","human_infant","human_pregnant","agricultural_worker"]}