{"hq_id":"hq-c-org-000138","name":"Captan","context":"human_adult","timestamp":"2026-08-28T02:49:23.678Z","risk_level":"moderate_to_high","risk_profile":{"magnitude":{"mean":0.513948,"weightedMean":0.513948,"std_dev":0.250186,"confidence_interval_95":[0.3,0.8],"source_positions":[{"source":"EPA CTX / CalEPA","year":2021,"value":0.8,"weight":0.30176},{"source":"US EPA","year":1999,"value":0.75,"weight":0.41},{"source":"HQ_DIRECT","year":2026,"value":0.3,"weight":0.35},{"source":"IARC","year":1983,"value":0.25,"weight":0.41}]},"confidence":{"mean":0.743901,"weightedMean":0.743901,"std_dev":0.136238,"confidence_interval_95":[0.82,0.82],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.5,"weight":0.35},{"source":"US EPA","year":1999,"value":0.82,"weight":0.41},{"source":"IARC","year":1983,"value":0.82,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.82,"weight":0.30176}]},"recency":{"mean":0.591841,"weightedMean":0.591841,"std_dev":0.233646,"confidence_interval_95":[0.5,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":1,"weight":0.35},{"source":"US EPA","year":1999,"value":0.5,"weight":0.41},{"source":"IARC","year":1983,"value":0.5,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.368,"weight":0.30176}]},"methodology":{"mean":0.928657,"weightedMean":0.928657,"std_dev":0.127723,"confidence_interval_95":[1,1],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.7,"weight":0.35},{"source":"US EPA","year":1999,"value":1,"weight":0.41},{"source":"IARC","year":1983,"value":1,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":1,"weight":0.30176}]},"specificity":{"mean":0.790428,"weightedMean":0.790428,"std_dev":0.072376,"confidence_interval_95":[0.92,0.92],"source_positions":[{"source":"HQ_DIRECT","year":2026,"value":0.92,"weight":0.35},{"source":"US EPA","year":1999,"value":0.75,"weight":0.41},{"source":"IARC","year":1983,"value":0.75,"weight":0.41},{"source":"EPA CTX / CalEPA","year":2021,"value":0.75,"weight":0.30176}]},"consensus":{"exists":false,"strength":0,"disagreement_magnitude":0.367097,"warning":null}},"interpretation":{"summary":"Regulatory agencies show substantial disagreement. EPA CTX / CalEPA classifies as higher risk (80th percentile), while IARC concludes lower risk (25th percentile).","confidence_note":"Moderate-quality evidence base. Disagreement reflects methodological and interpretive differences, not data quality issues.","context_note":null,"warning":null},"sources":[{"id":"epa_captan_iris","type":"regulatory","title":"US EPA IRIS: Captan — Cancer Classification B2 (Probable Human Carcinogen), Cancer Slope Factor, and Chronic Reference Dose (1999)","year":1999},{"id":"epa_captan_registration","type":"regulatory","title":"US EPA: Captan Registration Eligibility Decision — Dietary Risk Assessment, Occupational Exposure, Ecological Risk, and Reregistration Eligibility (2004)","year":2004}],"sources_scope":"context","warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 27 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 27 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): high frequ"],"meta":{"synthesis_version":"1.1.0","config_version":"1.1.0","n_sources":4,"db_version":52,"warnings":["year_inferred:EPA CTX / CalEPA:2021","unmapped_classification:EPA CTX / NIOSH:potential occupational carcinogen","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 27 positiv","unmapped_classification:EPA CTX / Genetox:genotoxicity: positive (ames: positive, 27 positiv","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: category 2 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: eye dam. 1 (score: very high)","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: skin sens. 1 (score: high)","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: category 8.3a (category 1) (score:","unmapped_classification:EPA CTX / Skin-Eye:skin sensitization: category 6.5b (category 1) (sc","unmapped_classification:EPA CTX / Skin-Eye:skin irritation: in vivo: moderate or mild irritat","unmapped_classification:EPA CTX / Skin-Eye:eye irritation: in vivo: corrosive or irritation p","unmapped_classification:EPA CTX / Skin-Eye:skin sensitisation: in vivo (non-llna): high frequ"]},"schema":"synthesis","_notice":"ALETHEIA output is reference data, not professional advice. Not a substitute for primary agency sources or qualified professionals. See https://aletheia.holisticquality.io/disclaimer.","_disclaimer_url":"https://aletheia.holisticquality.io/disclaimer","available_contexts":["human_adult","exposure_dermal","exposure_ingestion","human_teen","human_elderly","human_pregnant","agricultural_worker"]}